SML0475

CGP36742

≥97% (NMR)

• 別名: P-(3-Aminopropyl)-P-butyl-phosphinic acid, SGS 742
• 実験式（ヒル表記法）: C₇H₁₈NO₂P
• CAS番号: 123690-78-8
• 分子量: 179.20
• MDL番号: MFCD00882735
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825430
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (NMR)
• フォーム: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 10 mg/mL (clear solution, warmed)
• 保管温度: room temp
• SMILES記法: CCCCP(O)(=O)CCCN
• InChI: 1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
• InChI Key: ONNMDRQRSGKZCN-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

CGP36742 was the first orally active GABAB-selective antagonist. The IC₅₀ for blocking GABAergic transmission is 36 μM. Oral administration of CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model.

特徴および利点

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安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H319
• 注意書き: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable