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安全性情報

SML0491

Sigma-Aldrich

Ritonavir

≥98% (HPLC)

別名:

A-84538, ABT-538, Abbott 84538

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About This Item

実験式（ヒル表記法）:
C37H48N6O5S2
CAS番号:
155213-67-5
分子量:
720.94
MDL番号:
MFCD00927142
UNSPSCコード:
12352200
PubChem Substance ID:
329825441
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

フォーム

powder

色

white to beige

溶解性

DMSO: 10 mg/mL (clear solution, warmed)

保管温度

room temp

SMILES記法

O=C(OCC1=CN=CS1)N[C@H]([C@@H](O)C[C@@H](NC([C@@H](NC(N(CC2=CSC(C(C)C)=N2)C)=O)C(C)C)=O)CC3=CC=CC=C3)CC4=CC=CC=C4

InChI

1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI Key

NCDNCNXCDXHOMX-XGKFQTDJSA-N

アプリケーション

Ritonavir has been used:
  • as a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine function
  • as an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cells
  • as an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin

生物化学的／生理学的作用

Ritonavir is an HIV protease inhibitor now used frequently as a booster of other protease inhbitors. Ritonavir inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. It has also been investigated as a possible anti-cancer agent.

特徴および利点

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

ピクトグラム

Exclamation mark
GHS07

シグナルワード

Warning

危険有害性情報

H302 + H312 + H332

危険有害性の分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SML0491-10MG:
SML0491-50MG:
SML0491-BULK:
SML0491-VAR:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
0000219883
0000190743
0000190741
0000209341

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Slide 1 of 7

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Lopinavir Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1927

Lopinavir

Ritonavir-d6 ≥99 atom % D, ≥97% (CP)

Sigma-Aldrich

900923

Ritonavir-d6

vibrant-m

BP1210

Ritonavir

Arbidol hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0860

Arbidol hydrochloride

USP

USP

1604814

Ritonavir Related Compounds Mixture

リバビリン antiviral

Sigma-Aldrich

R9644

リバビリン

Fosamprenavir calcium ≥98% (HPLC)

Sigma-Aldrich

SML2101

Fosamprenavir calcium

José R Santos et al.
The Journal of antimicrobial chemotherapy, 70(4), 1124-1129 (2014-12-20)
Data on the efficacy of simplifying therapy using darunavir/ritonavir and lopinavir/ritonavir monotherapy in clinical practice remain limited. A retrospective single-centre study including patients initiating darunavir/ritonavir or lopinavir/ritonavir monotherapy with a plasma HIV-1 viral load (pVL) <50 copies/mL and at least
Lin Chen et al.
Journal of ethnopharmacology, 212, 74-85 (2017-10-23)
Radix Angelica dahuricae (RAD), the roots of Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav, is a well-known traditional Chinese medicine (TCM) and has been used for centuries to treat headaches, toothaches, nose congestion, abscesses, furunculoses, and acne.
Valerie L Flax et al.
The Journal of nutrition, 145(8), 1950-1957 (2015-07-15)
Little is known about the influence of antiretroviral therapy with or without micronutrient supplementation on the micronutrient concentrations of HIV-infected lactating women in resource-constrained settings. We examined associations of highly active antiretroviral therapy (HAART) and lipid-based nutrient supplements (LNS) with
Laura Ciaffi et al.
AIDS (London, England), 29(12), 1473-1481 (2015-08-06)
WHO recommends ritonavir-boosted protease inhibitor with two nucleoside reverse transcriptase inhibitors in HIV-infected patients failing non-nucleoside reverse transcriptase inhibitor-based first-line treatment. Here, we aimed to provide more evidence for the choice of nucleoside reverse transcriptase inhibitor and boosted protease inhibitor.
Mary S Ngoma et al.
Journal of the International AIDS Society, 18, 19352-19352 (2015-07-04)
To prevent mother-to-child transmission (MTCT) of HIV in developing countries, new World Health Organization (WHO) guidelines recommend maternal combination antiretroviral therapy (cART) during pregnancy, throughout breastfeeding for 1 year and then cessation of breastfeeding (COB). The efficacy of this approach
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資料

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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Discover Bioactive Small Molecules for ADME/Tox

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