SML0528

BIM5078

≥98% (HPLC)

• 別名: 1-(2′-Chloro-5′-nitrobenzenesulfonyl)-2-methylbenzimidazole, 1-[(2-Chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
• 実験式（ヒル表記法）: C₁₄H₁₀ClN₃O₄S
• CAS番号: 337506-43-1
• 分子量: 351.76
• MDL番号: MFCD01173148
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825533
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: CC1=NC2=CC=CC=C2N1S(C3=C(Cl)C=CC([N+]([O-])=O)=C3)(=O)=O
• InChI: 1S/C14H10ClN3O4S/c1-9-16-12-4-2-3-5-13(12)17(9)23(21,22)14-8-10(18(19)20)6-7-11(14)15/h2-8H,1H3
• InChI Key: DLUVMRPVZILBOE-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

BIM5078 is a potent Hepatocyte nuclear factor 4a (HNF4a) antagonist that directly binds to ligand-binding pocket and modulates the expression of known HNF4a target genes. BIM5078 also inhibits insulin gene expression by disruption of E47 and PDX-1 binding to insulin promoter. BIM5078 is selectively cytotoxic to transformed cells.

特徴および利点

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3