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Merck
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主要文書

安全性情報

SML0543

Sigma-Aldrich

p38 MAP Kinase Inhibitor IV

≥98% (HPLC)

別名:

2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol), B10, MT4

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About This Item

実験式（ヒル表記法）:
C12H4Cl6O4S
CAS番号:
1638-41-1
分子量:
456.94
UNSPSCコード:
12352200
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

フォーム

powder

色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

保管温度

2-8°C

SMILES記法

[S](=O)(=O)(c2c(c(cc(c2O)Cl)Cl)Cl)c1c(c(cc(c1O)Cl)Cl)Cl

InChI

1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H

InChI Key

AKUKHICVNCCQHN-UHFFFAOYSA-N

アプリケーション

p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling.

生物化学的／生理学的作用

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

特徴および利点

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SML0543-25MG:
SML0543-5MG:
SML0543-BULK:
SML0543-VAR:

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試験成績書（COA）

Lot/Batch Number
023M4729V

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Slide 1 of 10

1 of 10

p38 MAP Kinase Inhibitor XX, FGA-19

Sigma-Aldrich

5.30486

p38 MAP Kinase Inhibitor XX, FGA-19

p38 MAP Kinase Inhibitor X, BIRB 796 The p38 MAP Kinase Inhibitor X, BIRB 796, also referenced under CAS 285983-48-4, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

506172

p38 MAP Kinase Inhibitor X, BIRB 796

RU.521 ≥98% (HPLC)

Sigma-Aldrich

SML2347

RU.521

SB 202190 ≥98% (HPLC)

Sigma-Aldrich

S7067

SB 202190

PD 169316 ≥98% (HPLC), solid

Sigma-Aldrich

P9248

PD 169316

SP600125 ≥98% (HPLC)

Sigma-Aldrich

S5567

SP600125

コンブレタスタチンA4 ≥98% (HPLC), powder

Sigma-Aldrich

C7744

コンブレタスタチンA4

アルベンダゾールスルホキシド VETRANAL®, analytical standard

Supelco

35395

アルベンダゾールスルホキシド

PD 98,059 solid

Sigma-Aldrich

P215

PD 98,059

U0126 U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Sigma-Aldrich

19-147

U0126

Xujun He et al.
Oncotarget, 8(1), 1247-1261 (2016-12-03)
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資料

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

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