P9248

PD 169316

≥98% (HPLC), solid

• 別名: 4-(4-フルオロフェニル)-2-(4-ニトロフェニル)-5-(4-ピリジル)-1H-イミダゾール
• 実験式（ヒル表記法）: C₂₀H₁₃FN₄O₂
• CAS番号: 152121-53-4
• 分子量: 360.34
• MDL番号: MFCD12405019
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278156
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 色: faint yellow to dark orange
• 溶解性: DMSO: >10 mg/mL; H₂O: insoluble
• オーガナイザー: GlaxoSmithKline
• 保管温度: 2-8°C
• SMILES記法: [O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
• InChI Key: BGIYKDUASORTBB-UHFFFAOYSA-N
• 遺伝子情報: human ... MAPK14(1432)

詳細

詳細

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

アプリケーション

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

生物化学的／生理学的作用

p38 MAPキナ-ゼの強力かつ細胞浸透性の選択的インヒビタ-(IC₅₀ = 89 nM)です。

特徴および利点

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS06,GHS05
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H318,H335
• 注意書き: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves