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由来生物
Penicillium citrinum
品質水準
アッセイ
≥98% (HPLC)
形状
powder
溶解性
DMSO: 1 mg/mL
保管温度
−20°C
SMILES記法
OC1=C(C(CCCCC[C@H](C)O2)=O)C(CC2=O)=CC(O)=C1
InChI
1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1
InChI Key
VDUIGYAPSXCJFC-JTQLQIEISA-N
生物化学的／生理学的作用
S - Curvularin is a macrocyclic lactone with cytotoxic activity. Curvularin inhibits cell division as well as expression of human inducible nitric oxide synthase (iNOS), an enzyme critically involved in pro-inflammatory immune processes. Curvularin anti-inflammatory activity was demonstrated in chronic inflammatory disease models in mice such as Chronic Induced Arthritis (CIA) as well as in human alveolar epithelial A549/8 cells.
再構成
Soluble in DMSO (1 mg/mL), Chloroform (3 mg/mL) and Dichloromethane (3 mg/mL). Note: Insoluble in water.
その他情報
Store the product sealed at −20 °C. Under these conditions the product is stable for at least 5 years.
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML0772-1MG-PW:
SML0772-5MG:
SML0772-1MG:
SML0772-5MG-PW:
SML0772-BULK:
SML0772-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Birgitte Andersen et al.
International journal of food microbiology, 126(1-2), 172-179 (2008-07-05)
Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agents. Ulocladium spp. are often found on dead vegetation, in soil, air and
Lian Wu Xie et al.
Applied biochemistry and biotechnology, 159(1), 284-293 (2009-04-01)
With the anti-microbial and anti-tumor composite screening model, bioassay-guided fractionation led to the isolation of two structurally related bioactive compounds, curvularin and alphabeta-dehydrocurvularin, from ethyl acetate extract of Eupenicillium sp. associated with marine sponge Axinella sp. Further study on the
A new anthraquinone and cytotoxic curvularins of a Penicillium sp. from the rhizosphere of Fallugia paradoxa of the Sonoran desert.
Jixun Zhan et al.
The Journal of antibiotics, 57(5), 341-344 (2004-08-20)
Miyako Kusano et al.
Bioscience, biotechnology, and biochemistry, 67(6), 1413-1416 (2003-07-05)
The new nematicidal compound, betagamma-dehydrocurvularin (1), together with three known compounds, alphabeta-dehydrocurvularin (2), 8-beta-hydroxy-7-oxocurvularin (3) and 7-oxocurvularin (4), were isolated from the culture filtrate and mycelial mats of Aspergillus sp. The structures of 1-4 were established by spectroscopic methods including
[Molecular basis of probes for cytoskeletal proteins].
A Kobayashi et al.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 38(11), 1730-1741 (1993-08-01)
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