SML1463

NHI-2

≥98% (HPLC)

• 別名: 1-Hydroxy-6-phenyl-4-(trifluoromethyl)-1H-Indole-2-carboxylic acid methyl ester, Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
• 実験式（ヒル表記法）: C₁₇H₁₂F₃NO₃
• CAS番号: 1269802-97-2
• 分子量: 335.28
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825897
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: ON(C(C(OC)=O)=C1)C2=C1C(C(F)(F)F)=CC(C3=CC=CC=C3)=C2
• InChI: 1S/C17H12F3NO3/c1-24-16(22)15-9-12-13(17(18,19)20)7-11(8-14(12)21(15)23)10-5-3-2-4-6-10/h2-9,23H,1H3
• InChI Key: YPPFWRWCZNXINO-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). NHI-2 has anti-glycolytic activity against a variety of cancer cells. NHI-2 inhibited cell growth of pancreatic cancer LPC006 and PANC-1 cells and enhanced the antiproliferative effects of Gemcitabine and caused apoptosis in colon cancer HCT116 cells.

NHI-2 possesses highr cell permeability.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable