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SML1637

Hexaminolevulinate hydrochloride

Name: Hexaminolevulinate hydrochloride
Brand: SIGMA

≥98% (HPLC)

別名:

5-Aminolevulinic acid hexyl ester HAL hydrochloride, 5-Aminolevulinic acid hexyl ester hydrochloride, HAL, Hexvix, Hexyl 5-aminolevulinate hydrochloride, P 1206, n-Hexyl 5-aminolevulinate hydrochloride

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About This Item

実験式（ヒル表記法）:

C₁₁H₂₁NO₃ · HCl

CAS番号:

140898-91-5

分子量:

251.75

MDL番号:

MFCD03695491

UNSPSCコード:

12352200

PubChem Substance ID:

329825978

NACRES:

NA.77

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品質水準

100

アッセイ

≥98% (HPLC)

フォーム

powder

保管条件

desiccated

色

white to beige

溶解性

H₂O: 20 mg/mL, clear

保管温度

room temp

SMILES記法

CCCCCCOC(CCC(CN)=O)=O.[H]Cl

InChI

1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H

InChI Key

LZYXPFZBAZTOCH-UHFFFAOYSA-N

生物化学的／生理学的作用

Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis.