SML1822

Akebia saponin D

≥98% (HPLC)

• 別名: 3-O-α-L-arabinopyranosyl hederagenin-28-β-D-glucopyranoside-(1→6)-β-D-glucopyranoside, ASD, Asperosaponin VI, Leiyemudanoside A, Tauroside St-G0-1
• 実験式（ヒル表記法）: C₄₇H₇₆O₁₈
• CAS番号: 39524-08-8
• 分子量: 929.10
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: (Dipsacus asper)
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 光学活性: [α]/D +13 to +18°, c = 0.5 in methanol
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 3 mg/mL, clear (warmed)
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]5(C)[C@]6(C)CCC7[C@](C)(CO)[C@@H](O[C@]8([H])OC[C@H](O)[C@H](O)[C@H]8O)CC[C@]7(C)[C@@]6([H])CC=C5[C@]2([H])C1
• InChI: 1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1
• InChI Key: CCRXMHCQWYVXTE-HMRSNRLKSA-N

詳細

生物化学的／生理学的作用

Akebia saponin D (ASD) is a bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall that is used as an anti-osteoporosis drug. Akebia saponin D exhibits therapeutic effects in number of disease models including cancer, Alzheimer′s disease, cardiovascular disease, and bone fractures. Akebia saponin D protects against nonalcoholic fatty liver disease (NAFLD) liver damage in mice model of NAFLD. ASD decreases hepatic steatosis and heptocyte apoptosis through autophagy modulation. Akebia saponin D prevents oleic acid induced lipid droplets accumulation and increases autophagic flux BRL cells.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable