SML3513

Lorcaserin hydrochloride

≥98% (HPLC)

• 別名: (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride, (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride, APD 356 hydrochloride, APD-356 hydrochloride, APD356 hydrochloride
• 実験式（ヒル表記法）: C₁₁H₁₄ClN·HCl
• CAS番号: 846589-98-8
• 分子量: 232.15
• MDL番号: MFCD09833667
• UNSPSCコード: 12352200
• NACRES: NA.04

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 薬剤管理: USDEA Schedule IV
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 2 mg/mL, clear
• 保管温度: -10 to -25°C

詳細

生物化学的／生理学的作用

Lorcaserin is an orally active, potent and selective 5-hydroxytryptamine receptor (5-HT2C) agonist (human/rat Ki = 15 /29 nM) with 18- and 104-fold higher potency than 5-HT2A and 5-HT2B by cellular inositol phosphate accumulation assay (EC50 = 9, 168, 943 nM, respectively) and good selectivity over 5-HT1A/3/4C/5A/6/7 and a panel of 67 other GPCRs and ion channels. Chronic daily treatment to rats (4.5-18 mg/kg p.o. b.i.d.) maintained on a high fat diet causes reductions in food intake and body weight gain.

Orally active, potent and selective 5-hydroxytryptamine receptor (5-HT2C) agonist in vitro and in vivo.

注意

Hygroscopic

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H351
• 注意書き: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Carc. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable