SML3750

SR-302

≥98% (HPLC)

• 別名: N-(4-(((S)-4-Cyclohexyl-1-(((SR)-1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)imidazo[1,2-a]-pyridine-3-carboxamide, N-(4-((2S)-4-Cyclohexyl-1-(1-(methylsulfonyl)piperidin-3-ylamino)-1-oxobutan-2-ylcarbamoyl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide, SR 302, SR302
• 実験式（ヒル表記法）: C₃₂H₄₂N₆O₅S
• CAS番号: 2771319-74-3
• 分子量: 622.78
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C
• SMILES記法: O=C(NCC1=CC=C(C=C1)C(N[C@H](C(NC2CN(CCC2)S(=O)(C)=O)=O)CCC3CCCCC3)=O)C4=CN=C5C=CC=CN54

詳細

生物化学的／生理学的作用

SR-302 is an ATP-competitive, potent and selective inhibitor against DDR1/2 & MAPK11/14 (IC50/[ATP] = 53.3 nM/100 μM/DDR1, 0.75 nM/5 μM/DDR2; 45.1 nM/50 μM/MAPK11 (p38β), 6.2 nM/2.5 μM/MAPK14 (p38α) by cell-free kinase assay) with good cellular target actviity (IC50 = 18 nM/DDR2, 23 nM/DDR1, 125 nM/MAPK14, 196 nM/MAPK11 by NanoBRET) and kinome selectivity.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable