SRP4739

PLGF-1 ヒト

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• 別名: PGF, PIGF, PLGF 1, 胎盤増殖因子-1
• MDL番号: MFCD03458012
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥95% (HPLC); ≥95% (SDS-PAGE)
• 形状: lyophilized
• 分子量: ~29.7 kDa
• 包装: pkg of 25 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: endotoxin, tested
• NCBIアクセッション番号: AAD30179
• UniProtアクセッション番号: P49763
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... PGF(5228)

詳細

詳細

PLGF (placental growth factor), originally identified in human placenta, is a member of the VEGF (vascular endothelial growth factor) family. This protein is predominantly expressed in placenta, and also shows expression in heart, thyroid, lung and skeletal muscle. It is alternatively spliced to produce three isoforms in humans namely, PLGF1, PLGF2 and PLGF3.
Recombinant mouse PLGF is a disulfide-linked homodimer containing two 142 amino acid polypeptide chains.

生物化学的／生理学的作用

PLGF (placental growth factor) is involved in angiogenesis, but does not play an essential role in angiogenesis during reproduction and development. However, inactivation of this gene in pathological conditions such as, ischemia, inflammation and cancer, results in impaired angiogenesis. Preclinical studies show that this protein might be a therapeutic target for treatment of angiogenesis and inflammation related disorders. In acute coronary syndrome (ACS) patients, increased levels of PLGF are linked with obstructive sleep apnea (OSA) and short-term adverse outcomes.

物理的形状

凍結乾燥品(ろ過滅菌済み、添加物不含)。

再構成

バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。

Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffer.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable