SRP6317

C1 Esterase inhibitor from human plasma

≥95% (SDS-PAGE)

• 別名: エステラーゼインヒビターC1, 補体C1エステラーゼインヒビター
• UNSPSCコード: 12352204
• NACRES: NA.32

特性

• 由来生物: human
• アッセイ: ≥95% (SDS-PAGE)
• 形状: frozen liquid
• 分子量: 100 kDa
• 包装: pkg of 1 mg
• UniProtアクセッション番号: P05155
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... Serpin G1(710)

詳細

詳細

C1 esterase inhibitor is a single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, factors XIa, XIIa and plasmin of the blood clotting system. It is present in the plasma at 16-33 mg/100mL. It is part of the serpin family.

生物化学的／生理学的作用

C1 esterase inhibitor functions as a serine proteinase inhibitor. The concentration of C1 esterase inhibitor protein is reduced to 10-30% of normal in patients with angioedema secondary to C1 esterase inhibitor deficiency (85% of patients with Hereditary Angioedema (HAE)); in 15% of patients with HAE, the concentrations of the inhibitor protein is normal but function is markedly reduced. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary, though it may also occur when the protein is non-functional. C1 esterase inhibitor deficiencies also disturb the fibrinolytic system, the intrinsic coagulation pathway and the complement pathway.

物理的形状

Frozen in 20 mM potassium phosphate, pH 7.0, with 250 mM KCl.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable