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由来生物
bovine
品質水準
アッセイ
97-100% (agarose gel electrophoresis)
フォーム
powder
テクニック
cell culture | mammalian: suitable
UniProtアクセッション番号
保管温度
2-8°C
遺伝子情報
bovine ... TF(280705)
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詳細
Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.
アプリケーション
Holo-Transferrin bovine has been used:
- as a RPMI-1640 medium supplement for culturing cancer cell lines
- as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
- to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
- as a standard for strong anion exchange (SAX) reactor measurements
生物化学的／生理学的作用
Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.
アナリシスノート
アガロ-スゲル電気泳動によって純度測定。
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T1408-500MG:
T1408-50MG:
T1408-1G:
T1408-VAR:
T1408-BULK:
T1408-100MG:
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Holo-transferrin and thrombin can interact to cause brain damage
Nakamura T, et al.
Stroke, 36(2), 348-352 (2005)
Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry
Kaltashov IA, et al.
Biochim. Biophys. Acta Gen. Subj., 1820(3), 417-426 (2012)
Jillian R Gunther et al.
ACS chemical biology, 4(6), 435-440 (2009-05-16)
Compounds that directly disrupt the androgen receptor/steroid receptor coactivator interaction could function as novel inhibitors of androgen signaling that would remain effective in the treatment of prostate cancer that is resistant to conventional endocrine therapies. A structure-based peptidomimetic approach was
Metabolic restriction of cancer cells in vitro causes karyotype contraction?an indicator of cancer promotion?
Li Y, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 33(1), 195-205 (2012)
A single nucleotide polymorphism in the coding region of bovine transferrin is associated with milk fat yield
Sanz A, et al.
Genetics and molecular research : GMR, 9(2), 843-848 (2010)
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