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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen ~43 kDa
化学種の反応性
human, mouse, rat
濃度
~1.0 mg/mL
テクニック
immunohistochemistry: 5-10 μg/mL using rat, mouse, and human kidney
indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells
western blot: 1-2 μg/mL using human U2OS cell lysates
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TARDBP(23435)
詳細
TDP-43 (TAR DNA binding protein, TARDP) is a 414 amino acid nuclear protein and is a member of the heterogenous nuclear ribonucleoproteins (hnRNPs) family that bind single stranded RNA. It is encoded by the gene mapped to human chromosome 1p36.22. The encoded protein belongs to the family of heterogenous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is ubiquitously expressed and is characterized with two RNA-recognition motifs and a glycine-rich C-terminal region.
特異性
Anti-TDP-43 (C-terminal) specifically recognizes human, mouse, and rat TDP-43.
生物化学的／生理学的作用
Heterogeneous nuclear ribonucleoproteins (hnRNPs) play a vital role in generation and processing of RNA, including transcription, splicing, transport and stability. TDP-43 acts as a transcription regulator for human immunodeficiency virus (HIV). Abnormal phosphorylation of TDP-43 at Ser409/410 contributes to the pathology of frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS).
物理的形状
0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。
保管および安定性
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T1580-BULK:
T1580-25UL:
T1580-100UL:
T1580-200UL:
IXO15019:
T1580-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Yuriko Katsumata et al.
Acta neuropathologica communications, 6(1), 142-142 (2018-12-21)
TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology in specific
Clara Bruno et al.
Brain communications, 2(2), fcaa133-fcaa133 (2020-10-03)
Loss-of-function mutations in TANK-binding kinase 1 cause genetic amyotrophic lateral sclerosis and frontotemporal dementia. Consistent with incomplete penetrance in humans, haploinsufficiency of TANK-binding kinase 1 did not cause motor symptoms in mice up to 7 months of age in a previous
The role of TDP-43 in amyotrophic lateral sclerosis and frontotemporal dementia
Mackenzie, Ian RA and Rademakers, Rosa
Current Opinion in Neurology, 21(6), 693-693 (2008)
Pei-Yi Lin et al.
Journal of neuroscience research, 94(7), 671-682 (2016-03-21)
TAR DNA binding protein 43 (TDP-43) is a nuclear protein that has been shown to have altered homeostasis in the form of neuronal nuclear and cytoplasmic aggregates in some familial and almost all cases of sporadic amyotrophic lateral sclerosis as
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
Ayala YM, et al.
Proceedings of the National Academy of Sciences, 105(10), 3785-3789 (2008)
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