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Merck
모든 사진(2)

문서

123080

Sigma-Aldrich

2-Amino-4-methylpyridine

99%

동의어(들):

2-Amino-4-picoline

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C6H8N2
CAS Number:
695-34-1
Molecular Weight:
108.14
Beilstein:
107066
EC Number:
211-780-9
MDL number:
MFCD00006321
UNSPSC 코드:
12352100
PubChem Substance ID:
24847520
NACRES:
NA.22

Quality Level

100

분석

99%

bp

230 °C (lit.)

mp

96-99 °C (lit.)

solubility

DMF: freely soluble
H2O: freely soluble
aliphatic hydrocarbons: slightly soluble
coal tar bases: freely soluble
lower alcohols: freely soluble
petroleum ether: slightly soluble

SMILES string

Cc1ccnc(N)c1

InChI

1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)

InChI key

ORLGLBZRQYOWNA-UHFFFAOYSA-N

유전자 정보

human ... NOS1(4842) , NOS2(4843) , NOS3(4846)
rat ... Nos1(24598)

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일반 설명

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.

애플리케이션

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl­pyridinium 2-hy­droxy­benzoate.

생화학적/생리학적 작용

2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

픽토그램

Skull and crossbonesCorrosion
GHS06,GHS05

신호어

Danger

유해 및 위험 성명서

H301 + H311 + H331,H314,H412

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point (°F)

244.4 °F - closed cup

Flash Point (°C)

118 °C - closed cup

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

시험 성적서(COA)

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문서 라이브러리 방문

R Boer et al.
Molecular pharmacology, 58(5), 1026-1034 (2000-10-20)
We have investigated various nitric oxide (NO) synthase inhibitors for their affinity and selectivity toward the three human isoenzymes in radioligand binding experiments. Therefore, we developed the new radioligand [(3)H]2-amino-4-picoline to measure binding of these compounds to the three human
W S Faraci et al.
British journal of pharmacology, 119(6), 1101-1108 (1996-11-01)
1. The ability of 2-amino-4-methylpyridine to inhibit the catalytic activity of the inducible NO synthase (NOS II) enzyme was characterized in vitro and in vivo. 2. In vitro, 2-amino-4-methylpyridine inhibited NOS II activity derived from mouse RAW 264.7 cells with
Sherif Y Saad et al.
Chemotherapy, 48(6), 309-315 (2003-04-04)
Nitric oxide (NO) has been shown to play a role in maintaining normal renal function. However, the role of NO in cisplatin (CDDP)-induced nephrotoxicity is still unclear. The aim of the present work was to examine the effect of the
N Kiloh et al.
European journal of pharmacology, 70(1), 53-57 (1981-03-05)
4-Methyl-2-aminopyridine (4M2AP) increased responses of isolated rat diaphragm and chick biventer cervicis nerve-muscle preparations to nerve stimulation but depressed responses to direct stimulation. Responses to acetylcholine were also increased while responses to carbachol were depressed. When tested after inhibition of
Madhukar Hemamalini et al.
Acta crystallographica. Section E, Structure reports online, 66(Pt 8), o2151-o2152 (2010-01-01)
The asymmetric unit of the title mol-ecular salt, C(6)H(9)N(2) (+)·C(7)H(5)O(3) (-), contains two cations and two anions. Both the salicylate anions contain an intra-molecular O-H⋯O hydrogen bond, which generates an S(6) ring. Both the 2-amino-4-methyl-pyridine mol-ecules are protonated at their
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