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Merck
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Key Documents

183660

Sigma-Aldrich

3,3-Dimethylacryloyl chloride

97%, contains 400 ppm phenothiazine as inhibitor

동의어(들):

3-Methyl-2-butenoyl chloride, 3-Methylcrotonoyl chloride, Senecioyl chloride

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About This Item

Linear Formula:
(CH3)2C=CHCOCl
CAS Number:
Molecular Weight:
118.56
Beilstein:
1560268
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

분석

97%

형태

liquid

포함

400 ppm phenothiazine as inhibitor

refractive index

n20/D 1.476 (lit.)

bp

145-147 °C (lit.)

density

1.065 g/mL at 25 °C (lit.)

SMILES string

C\C(C)=C\C(Cl)=O

InChI

1S/C5H7ClO/c1-4(2)3-5(6)7/h3H,1-2H3

InChI key

BDUBTLFQHNYXPC-UHFFFAOYSA-N

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일반 설명

3,3-Dimethylacryloyl chloride reacts with silylketene acetals in acetonitrile to give δ-ethylenic β-keto esters.

애플리케이션

3,3-Dimethylacryloyl chloride was used in the synthesis of:
  • substituted 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one via condensation with aniline
  • N-(3,3-Dimethylacryloyl)-(S)-leucine methyl ester

픽토그램

FlameCorrosionExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - STOT SE 3

표적 기관

Respiratory system

보충제 위험성

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point (°F)

123.8 °F - closed cup

Flash Point (°C)

51 °C - closed cup

개인 보호 장비

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

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European journal of medicinal chemistry, 43(8), 1730-1736 (2008-01-01)
A new series of substituted 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one have been prepared via condensation of 3,3-dimethylacryloyl chloride with aniline. Details of synthetic procedures are shown. Our aim was to investigate the potency of our original heterocycle in the inhibition of the Rho-kinase enzyme
Reaction of silylketene acetals with 3, 3-dimethylacryloyl chloride.
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