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Merck
모든 사진(3)

주요 문서

202444

Sigma-Aldrich

Poly(ethylene glycol)

average MN 3,350, hydroxyl, powder

동의어(들):

Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
UNSPSC 코드:
12352104
PubChem Substance ID:
NACRES:
NA.23

제품명

Poly(ethylene glycol), average Mn 3,350, powder

양식

powder

Quality Level

분자량

average Mn 3,350

pH

4.5-7.5

점도

90 cSt(210 °F) (99 °C)(lit.)

mp

54-58 °C (lit.)

density

1.204 g/mL at 25 °C

Ω-끝

hydroxyl

α-끝

hydroxyl

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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일반 설명

Poly(ethylene glycol) (PEG) is a biocompatible inert synthetic polymer with repeating units of ether oxygen (-CH2-CH2-O-). It can be synthesized via anionic polymerization of ethylene oxide. It is extensively used in biological and medical applications due to its non-immunogenicity and high water solubility.

애플리케이션

PEG can be used to functionalize magnetite nanoparticles. The coating of the magnetic core with PEG provides good stabilization while maintaining the magnetic properties of the nanoparticles.

It can be used to modify the surface of photocatalytic TiO2 nanopowder for its application in self-cleaning paints. PEG-coated TiO2 nanopowder can be prepared under mild conditions and show excellent colloidal stability.

It can be used as a cross-linker to prepare poly(N-isopropylacrylamide) based thermosensitive injectable hydrogels. The addition of PEG improves the chemical and mechanical properties of hydrogel and prevents it from dissolving in the swelling medium. Owing to their biocompatibility and biodegradability, these hydrogels are widely used for biomedical applications.

특징 및 장점

  • High structural flexibility
  • Biocompatibility
  • High hydration capacity
  • Devoid of any steric hindrance

기타 정보

Molecular weight: Mn 3,015-3,685

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Grant A Robinson et al.
Journal of neuroscience research, 94(7), 636-644 (2016-03-21)
Functional recovery following a peripheral nerve injury is made easier when regenerating axons correctly reinnervate their original targets. Polyethylene glycol (PEG) has recently been used in attempts to fuse severed peripheral axons during suture-based repair, but an analysis of target
Erinna F Lee et al.
Autophagy, 15(5), 785-795 (2019-01-11)
BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at threonine 108 (T108) within its BH3 domain blocks macroautophagy/autophagy by increasing BECN1 affinity for its negative regulators
Yixu Wang et al.
mSphere, 4(3) (2019-05-31)
Sporisorium scitamineum is the fungal pathogen causing severe sugarcane smut disease that leads to massive economic losses globally. S. scitamineum invades host cane by dikaryotic hyphae, formed after sexual mating of two haploid sporidia of opposite mating type. Therefore, mating/filamentation
Mark A Rice et al.
Acta biomaterialia, 5(1), 152-161 (2008-09-17)
Ultrasound has potential as a non-destructive analytical technique to provide real-time online assessments of matrix evolution in cell-hydrogel constructs used in tissue engineering. In these studies, chondrocytes were encapsulated in poly(ethylene glycol) hydrogels, and gel degradation was manipulated to provide
Idalis Villanueva et al.
Acta biomaterialia, 5(8), 2832-2846 (2009-06-11)
The pericellular matrix (PCM) surrounding chondrocytes is thought to play an important role in transmitting biochemical and biomechanical signals to the cells, which regulates many cellular functions including tissue homeostasis. To better understand chondrocytes interactions with their PCM, three-dimensional poly(ethylene

문서

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

조직 공학과 약물 전달과 같은 생명 공학의 진보는 다양한 기능성 바이오 소재에 대한 수요 증가를 동반합니다. 연구의 집중 관심 대상이 되어온 바이오 소재의 한 분야는 바로 하이드로겔으로, 화학적으로나 물리적으로 세포의 자연 환경과 유사하게 닮아 있기 때문에 세포를 키우는 토대로 사용될 수 있습니다. 본 기술 문서에서는 일반적으로 면역 반응을 유발하지 못하기 때문에 생물학적 용도로 적합한 PEG(폴리에틸렌 글리콜) 하이드로겔에 대해 상세하게 논의합니다. PEG는 쉽게 이용할 수 있으며, 손쉽게 고분자를 수정하여 세포 배양을 위한 2D 및 3D 뼈대를 포함한 하이드로겔 구성에 광범위하게 사용할 수 있습니다. 또한 분해성 결합을 통해 치료제 출시를 위한 다양한 응용분야에도 도움을 줍니다.

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

관련 콘텐츠

Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.