모든 사진(1)
About This Item
Linear Formula:
[Ru(CO)3Cl2]2
CAS Number:
Molecular Weight:
512.01
MDL number:
UNSPSC 코드:
12161600
PubChem Substance ID:
NACRES:
NA.22
추천 제품
Quality Level
반응 적합성
core: ruthenium
reagent type: catalyst
SMILES string
[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].Cl[Ru]Cl.Cl[Ru]Cl
InChI
1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4
InChI key
JYHHJVKGDCZCCL-UHFFFAOYSA-J
애플리케이션
Carbon monoxide-releasing molecule used for pharamological studies including:
Used as a CO donor for reactive oxygen species mediated bacterial killing
- Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
- Investigations of P2X4 as a possible target
- Possible modification of thrombus growth or disintegration
- Enhances fibrinogen as a substrate for thrombin
- Regulation of ion transport by gasotransmitters
Used as a CO donor for reactive oxygen species mediated bacterial killing
Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines. It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
이미 열람한 고객
![[Ru(phen)3]Cl2 ≥95%](/deepweb/assets/sigmaaldrich/product/structures/955/596/46f63eaa-39f8-4058-847d-cef0862ada92/640/46f63eaa-39f8-4058-847d-cef0862ada92.png)
Francisco J Ibáñez et al.
Frontiers in microbiology, 8, 2108-2108 (2017-11-23)
Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others. Its activity can be positively modulated by
Yu Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 36(6), 791-795 (2016-12-08)
Carbon monoxide (CO), as a vital small molecule in signaling pathways, is found to be involved in ischemia-reperfusion injury (IRI) in renal transplantation. CO-releasing molecule-2 (CORM-2), a CO-releasing molecule, is a type of metal carbonyl complexes which can quickly release
V G Nielsen et al.
Human & experimental toxicology, 36(7), 727-733 (2016-08-05)
Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of
Vance G Nielsen et al.
Basic & clinical pharmacology & toxicology, 122(1), 157-164 (2017-07-12)
Several in vitro investigations have demonstrated that anticoagulant effects of fibrinogenolytic snake venom metalloproteinases have been abrogated in human plasma by modifying fibrinogen with iron (Fe) and carbon monoxide (CO) to prevent catalysis or by directly inhibiting these enzymes with CO.
Vance G Nielsen
International journal of molecular sciences, 21(8) (2020-04-29)
The demonstration that carbon monoxide releasing molecules (CORMs) affect experimental systems by the release of carbon monoxide, and not via the interaction of the inactivated CORM, has been an accepted paradigm for decades. However, it has recently been documented that
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