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Merck
모든 사진(1)

문서

41996

Sigma-Aldrich

1-Hydroxy-7-azabenzotriazole solution

~0.6 M in DMF, for peptide synthesis

동의어(들):

3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt

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About This Item

실험식(Hill 표기법):
C5H4N4O
CAS Number:
Molecular Weight:
136.11
Beilstein:
1211115
MDL number:
UNSPSC 코드:
12352005
PubChem Substance ID:
NACRES:
NA.22

product name

1-Hydroxy-7-azabenzotriazole solution, ~0.6 M in DMF

형태

liquid

반응 적합성

reaction type: Addition Reactions

농도

~0.6 M in DMF

불순물

<1.0% water

refractive index

n20/D 1.441

density

0.978 g/mL at 20 °C

응용 분야

peptide synthesis

SMILES string

On1nnc2cccnc12

InChI

1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H

InChI key

FPIRBHDGWMWJEP-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

1-Hydroxy-7-azabenzotriazole solution, also known as 3H-[1,2,3]-triazolo[4,5-b]pyridin-3-ol, is a benzotriazolic additive that is commonly used as a coupling reagent for amino acids and peptides. It is also used to minimize epimerization.

애플리케이션

1-Hydroxy-7-azabenzotriazole solution is used as a reagent in the solid-phase synthesis of chiral peptide nucleic acids.

기타 정보

Coupling additive for efficient racemization-free coupling in peptide synthesis; segment coupling.

픽토그램

FlameHealth hazardExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point (°F)

136.4 °F - closed cup

Flash Point (°C)

58 °C - closed cup

개인 보호 장비

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

L.A. Carpino, A. El-Faham
Tetrahedron, 55, 6813-6813 (1999)
Synthesis of chiral peptide nucleic acids using Fmoc chemistry
Yun W and Jie-Cheng X
Tetrahedron, 57, 8107-8113 (2001)
Júlia García-Pindado et al.
Biopolymers, 109(10), e23112-e23112 (2018-03-13)
While revisiting biologically active natural peptides, the importance of the tryptophan residue became clear. In this article, the incorporation of this amino acid, brominated at different positions of the indole ring, into cyclic peptides was successfully achieved. These products demonstrated
Simone Di Micco et al.
Frontiers in chemistry, 8, 628609-628609 (2021-02-02)
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Hsuan-Ni Lin et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 34(11), 1883-1893 (2016-02-27)
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