54802

1-Hydroxybenzotriazole hydrate

≥97.0% dry basis (T), for peptide synthesis

• 동의어(들): HOBt Hydrate
• 실험식(Hill 표기법): C₆H₅N₃O · xH₂O
• CAS Number: 123333-53-9
• Molecular Weight: 135.12 (anhydrous basis)
• Beilstein: 4515
• EC Number: 219-989-7
• UNSPSC 코드: 12352000
• PubChem Substance ID: 57651485
• NACRES: NA.22

속성

• product name: 1-Hydroxybenzotriazole hydrate, ≥97.0% dry basis (T)
• Quality Level: 200
• 분석: ≥97.0% dry basis (T)
• 형태: solid
• 구성: water, ~12%
• 반응 적합성: reaction type: Addition Reactions
• mp: 155-158 °C (lit.)
• solubility: DMF: 0.1 g/mL, clear
• 응용 분야: peptide synthesis
• SMILES string: [H]O[H].On1nnc2ccccc12
• InChI: 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
• InChI key: PJUPKRYGDFTMTM-UHFFFAOYSA-N

설명

일반 설명

1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.

애플리케이션

1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:

• Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
• Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.

기타 정보

Widely used additive to decrease racemization in the carbodiimide peptide coupling; Racemization-free condensation of peptide fragments

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H207,H319,H412
• 예방조치 성명서: P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
• Hazard Classifications: Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
• Storage Class Code: 4.1A - Other explosive hazardous materials
• WGK: WGK 1
• Flash Point (°F): 314.6 °F
• Flash Point (°C): 157 °C