470260
4-Methoxyphenylmagnesium bromide solution
0.5 M in THF
동의어(들):
(4-Methoxyphenyl)magnesium bromide, 4-Anisylmagnesium bromide, p-Methoxyphenylmagnesium bromide, Bromo(4-methoxyphenyl)magnesium
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모든 사진(1)
About This Item
Linear Formula:
CH3OC6H4MgBr
CAS Number:
Molecular Weight:
211.34
MDL number:
UNSPSC 코드:
12352103
PubChem Substance ID:
NACRES:
NA.22
추천 제품
반응 적합성
reaction type: Grignard Reaction
Quality Level
농도
0.5 M in THF
bp
65-67 °C
density
0.955 g/mL at 25 °C
SMILES string
COc1ccc([Mg]Br)cc1
InChI
1S/C7H7O.BrH.Mg/c1-8-7-5-3-2-4-6-7;;/h3-6H,1H3;1H;/q;;+1/p-1
InChI key
JKXAZEXIOPFJSC-UHFFFAOYSA-M
애플리케이션
4-Methoxyphenylmagnesium bromide is a general Grignard reagent that can be used:
- In the denickelation of porphyrins and to replace the metal center with magnesium.
- To synthesize a tubulin polymerization inhibitor, 2-Amino-3,4,5-trimethoxybenzophenone.
- In the total synthesis of (−)-centrolobine.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
표적 기관
Central nervous system, Respiratory system
보충제 위험성
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point (°F)
-4.0 °F
Flash Point (°C)
-20 °C
이미 열람한 고객
Two successive one-pot reactions leading to the expeditious synthesis of (−)-centrolobine.
Boulard L, et al.
Tetrahedron Letters, 45(35), 6603-6605 (2004)
Demetalation of Metal Porphyrins via Magnesium Porphyrins by Reaction with Grignard Reagents.
Murakami K, et al.
Chemistry?A European Journal , 19(28), 9123-9126 (2013)
2?Amino?3, 4, 5?Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors.
Chuang H Y, et al.
ChemMedChem, 6(3), 450-456 (2011)
Ryosuke Koyama et al.
Bioorganic & medicinal chemistry, 28(11), 115492-115492 (2020-04-16)
Effective chemotherapy for solid cancers is challenging due to a limitation in permeation that prevents anticancer drugs from reaching the center of the tumor, therefore unable to limit cancer cell growth. To circumvent this issue, we planned to apply the
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