526797

Cyclopropylmagnesium bromide solution

0.5 M in THF

• 동의어(들): Bromocyclopropylmagnesium
• 실험식(Hill 표기법): C₃H₅BrMg
• CAS Number: 23719-80-4
• Molecular Weight: 145.28
• MDL number: MFCD00672094
• UNSPSC 코드: 12352103
• PubChem Substance ID: 24874579
• NACRES: NA.22

속성

• 반응 적합성: reaction type: Grignard Reaction
• 농도: 0.5 M in THF
• bp: 65 °C
• density: 0.968 g/mL at 25 °C
• 저장 온도: 2-8°C
• SMILES string: Br[Mg]C1CC1
• InChI: 1S/C3H5.BrH.Mg/c1-2-3-1;;/h1H,2-3H2;1H;/q;;+1/p-1
• InChI key: QUPLLJGAJVXXBW-UHFFFAOYSA-M

설명

애플리케이션

Cyclopropylmagnesium bromide solution has been used in Grignard reaction that finds application as the key step in the preparation of aminopropylindenes, a chemotype of oxidosqualene cyclase (OSC) inhibitors from Grundmann′s ketone. It can react with trimethylborate to form cyclopropylboronic acid, which can undergo Suzuki-type coupling reactions with different aryl, and heteroaryl bromides to form the cyclopropyl adducts.

안전성 정보

• 픽토그램: GHS02,GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H261,H302,H314,H335,H336,H351
• 예방조치 성명서: P210 - P231 + P232 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3 - Water-react 2
• 표적 기관: Central nervous system, Respiratory system
• 보충제 위험성: EUH019
• Storage Class Code: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• WGK: WGK 3
• Flash Point (°F): 1.0 °F - closed cup
• Flash Point (°C): -17.22 °C - closed cup