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Merck
모든 사진(2)

주요 문서

857120P

Avanti

14:0 Lyso PA

1-myristoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), powder

동의어(들):

1-tetradecanoyl-sn-glycero-3-phosphate (sodium salt); PA(14:0/0:0); 14:0 LPA; 110677

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About This Item

실험식(Hill 표기법):
C17H34O7PNa
CAS Number:
Molecular Weight:
404.41
UNSPSC 코드:
51191904
NACRES:
NA.25

분석

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

양식

powder

포장

pkg of 1 × 25 mg (857120P-25mg)
pkg of 1 × 500 mg (857120P-500mg)

제조업체/상표

Avanti Research - A Croda Brand 857120P

지질 유형

phospholipids
cardiolipins

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C17H35O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-17(19)23-14-16(18)15-24-25(20,21)22;/h16,18H,2-15H2,1H3,(H2,20,21,22);/q;+1/p-1/t16-;/m1./s1

InChI key

HGENTPHNTSLRPB-PKLMIRHRSA-M

일반 설명

Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position.

애플리케이션

14:0 Lyso PA is suitable to use as internal standard to spike serum samples for the extraction of serum lipids. It is also suitable to use as standard lipids for extraction of lipids and for quality control in multiple reaction monitoring (MRM) assay.

생화학적/생리학적 작용

Lysophosphatidic acid (LPA) participates in several biological functions. It acts as a potential biomarker for detecting ovarian cancer. LPA stimulates platelet aggregation, smooth muscle contraction, chemotaxis, cytoskeleton rearrangement, Ca2+ mobilization, neurotransmitter release and cell proliferation.

포장

20 mL Clear Glass Screw Cap Vial (857120P-500mg)
5 mL Amber Glass Screw Cap Vial (857120P-25mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells
Li L, et al.
Journal of Chromatography A, 1381(2), 140-148 (2015)
Determination of lysophosphatidic acids by capillary electrophoresis with indirect ultraviolet detection
Chen YL and Xu Y
Journal of Chromatography. B, Biomedical Sciences and Applications, 753(2), 355-363 (2001)
Quantitative determination of lysophosphatidic acid by LC/ESI/MS/MS employing a reversed phase HPLC column
Shan L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 22-28 (2008)
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Jesica R Williams et al.
The Journal of biological chemistry, 284(25), 17304-17319 (2009-04-16)
Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. Because the structure-activity relationship (SAR) of GPR92/LPA(5) is limited and whether LPA is its

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