추천 제품
양식
powder
포장
pkg of 1 × 1 mg (860658P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 860658P
배송 상태
dry ice
저장 온도
−20°C
SMILES string
OC[C@@](N)([H])[C@@](O)([H])CCCCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1/i1D3,2D2,3D2
InChI key
OTKJDMGTUTTYMP-GEZFCKIXSA-N
일반 설명
Sphinganine-d7 is a deuterated derivative of sphinganine. Sphinganine, also called as dihydrosphingosine is a derivative of sphingosine. Sphinganines are produced in endoplasmic reticulum, by decarboxylating condensation of palmitoyl-CoA and serine.
애플리케이션
Sphinganine-d7 has been used as an internal standard for quantification of sphingolipid concentrations in plasma and tissue samples by high-performance liquid chromatography tandem mass spectrometry.
생화학적/생리학적 작용
Sphinganine (SPA) acts as a selective inhibitor of protein kinase C in intact human neutrophils. It may function a potential biomarker for the diagnosis of sphingolipidoses. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.
포장
5 mL Amber Glass Screw Cap Vial (860658P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
가장 최신 버전 중 하나를 선택하세요:
Lipids
Basic neurochemistry: principles of molecular, cellular, and medical neurobiology (2011)
Gennaro Bruno et al.
Cellular signalling, 45, 110-121 (2018-02-07)
Skeletal muscle tissue retains a remarkable regenerative capacity due to the activation of resident stem cells that in pathological conditions or after tissue damage proliferate and commit themselves into myoblasts. These immature myogenic cells undergo differentiation to generate new myofibers
Federica Storti et al.
eLife, 8 (2019-03-14)
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (ABCA1), have been associated
D Pittet et al.
The Journal of biological chemistry, 262(21), 10072-10076 (1987-07-25)
Sphinganine has been proposed to be a specific inhibitor of protein kinase C. In the present study we have evaluated whether sphinganine is a convenient tool to probe for the role of protein kinase C in neutrophil function. Human neutrophils
Graham Brogden et al.
Biomolecules, 9(9) (2019-09-11)
Sphingolipids are an important group of lipids that play crucial roles in living cells, facilitating cell recognition, signal transduction and endocytosis. The concentration of sphingosine and some of its derivatives like sphinganine may serve as a biomarker for the diagnosis
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