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Merck
모든 사진(1)

문서

860626P

Avanti

C8 Dihydroceramide (d18:0/8:0)

Avanti Research - A Croda Brand 860626P, powder

동의어(들):

N-octanoyl-D-erythro-sphinganine

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About This Item

실험식(Hill 표기법):
C26H53NO3
CAS Number:
Molecular Weight:
427.70
UNSPSC 코드:
12352211
NACRES:
NA.25

형태

powder

포장

pkg of 1 × 5 mg (860626P-5mg)

제조업체/상표

Avanti Research - A Croda Brand 860626P

지질 유형

sphingolipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

InChI

1S/C26H53NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h24-25,28-29H,3-23H2,1-2H3,(H,27,30)/t24-,25+/m0/s1

InChI key

LGOFBZUQIUVJFS-LOSJGSFVSA-N

애플리케이션

C8 Dihydroceramide (d18:0/8:0) has been used as an internal standard to quantify the lipid extracted from human plasma by liquid chromatography mass spectrometry during high-throughput plasma lipidomics.

생화학적/생리학적 작용

C8 Dihydroceramide (d18:0/8:0) or N-octanoyl-D-erythro-sphinganine, is a synthetic dihydroceramide. Dihydroceramide acts as a precursor for de-novo ceramide synthesis. C8 Dihydroceramide mimics γ-tocotrienol (γTE) in stimulating NF-κB-target protein A20 expression, increasing endoplasmic reticulum (ER) stress and reducing tumor necrosis factor (TNF)-triggered nuclear factor kappa B (NF-κB) activation.

포장

5 mL Amber Glass Screw Cap Vial (860626P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


시험 성적서(COA)

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문서 라이브러리 방문

Vitamin E gamma-tocotrienol inhibits cytokine-stimulated NF-kappaB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids
Wang Y, et al.
Journal of Immunology, 195(1), 126-133 (2015)
Yun Wang et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 126-133 (2015-05-24)
NF-κB plays a central role in pathogenesis of inflammation and cancer. Many phytochemicals, including γ-tocotrienol (γTE), a natural form of vitamin E, have been shown to inhibit NF-κB activation, but the underlying mechanism has not been identified. In this study
Jennifer T Saville et al.
Journal of inherited metabolic disease, 43(3), 558-563 (2019-11-11)
Gaucher disease (GD) is an inherited metabolic disorder characterised by impaired catabolism of the glycosphingolipid, glucosylceramide. The deacetylated derivative, glucosylsphingosine (GluSph, lyso-Gb1) has materialised as a biomarker for GD. Further appraisal of the clinical utility of GluSph is required in
Low serum levels of (dihydro-) ceramides reflect liver graft dysfunction in a real-world cohort of patients post liver transplantation
Mucke V, et al.
International Journal of Molecular Sciences, 19(4), 991-991 (2018)
Victoria Therese Mücke et al.
International journal of molecular sciences, 19(4) (2018-03-29)
Patients after orthopic liver transplantation (OLT) are at risk of developing graft dysfunction. Sphingolipids (SL's) have been identified to play a pivotal role in the regulation of hepatocellular apoptosis, inflammation and immunity. We aimed to investigate the serum SL profile

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