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Merck
모든 사진(1)

주요 문서

L-025

Supelco

(−)-Levamisole hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

실험식(Hill 표기법):
C11H12N2S
CAS Number:
Molecular Weight:
204.29
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

certified reference material

Quality Level

형태

liquid

특징

Snap-N-Spike®/Snap-N-Shoot®

포장

ampule of 1 mL

제조업체/상표

Cerilliant®

농도

1.0 mg/mL in methanol (as free base)

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

응용 분야

pharmaceutical (small molecule)

형식

single component solution

저장 온도

−20°C

SMILES string

C1CN2C[C@@H](N=C2S1)c3ccccc3

InChI

1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1

InChI key

HLFSDGLLUJUHTE-SNVBAGLBSA-N

일반 설명

Levamisole, an antihelminthic drug used to treat worm infestations in humans and animals, is an adulterant and cutting agent found in cocaine sold in the US and Canada. From 2008-2009, levamisole was detected in 69% of cocaine samples seized by the US Drug Enforcement Administration (DEA).

애플리케이션


  • Immunomodulatory research: The study explored the potential immunomodulatory effects of levamisole hydrochloride in humans and farm animals, highlighting its utility in enhancing immune responses and its therapeutic potential across a range of conditions (Gholami et al., 2023).

  • Anthelmintic research: A study developed a real-time detection method for the levamisole resistance variant in Haemonchus contortus, illustrating the role of levamisole hydrochloride in understanding and managing anthelmintic resistance (Antonopoulos et al., 2024).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

FlameSkull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point (°F)

49.5 °F - closed cup

Flash Point (°C)

9.7 °C - closed cup


시험 성적서(COA)

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문서 라이브러리 방문

Anders N Hansen et al.
PloS one, 7(9), e45405-e45405 (2012-10-02)
Inhibition of angiogenesis is a promising addition to current cancer treatment strategies. Neutralization of vascular endothelial growth factor by monoclonal antibodies is clinically effective but may cause side effects due to thrombosis. Low molecular weight angiogenesis inhibitors are currently less
Bashir A Lone et al.
Tropical animal health and production, 45(3), 743-749 (2012-10-16)
The aim of this study was to evaluate the anthelmintic and antimicrobial efficacy of Euphorbia helioscopia crude extracts. A worm motility inhibition assay and egg hatch assay were used for in vitro study, and a faecal egg count reduction assay
Jonathan Graf
Current opinion in rheumatology, 25(1), 50-55 (2012-12-01)
Cocaine use is associated with several rheumatic syndromes. This review summarizes these clinical manifestations and highlights recent developments linked to levamisole-adulterated cocaine. Cocaine use has been linked to several distinctive syndromes that can be difficult to distinguish from idiopathic rheumatic
Lauren Strazzula et al.
Journal of the American Academy of Dermatology, 69(6), 954-959 (2013-10-01)
Levamisole is present as a contaminant or additive in most cocaine sold in the United States. Cases of agranulocytosis attributed to levamisole-tainted cocaine have been widely described. A vasculopathic reaction to levamisole has also been reported; however, diagnostic features such as
Xingxin Li et al.
Annals of hematology, 92(9), 1239-1247 (2013-04-27)
The appropriate management of patients with moderate aplastic anemia (mAA) remains to be unclear and controversial. A cohort of 118 patients with mAA received a novel immunosuppressive strategy of cyclosporine alternately combined with levamisole (CSA and LMS regimen), which included

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