N-008
S(−)-Nicotine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
동의어(들):
(−)-Nicotine solution
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C10H14N2
CAS Number:
Molecular Weight:
162.23
Beilstein:
5733110
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24
추천 제품
Grade
certified reference material
형태
liquid
특징
Snap-N-Spike®/Snap-N-Shoot®
포장
ampule of 1 mL
제조업체/상표
Cerilliant®
농도
1.0 mg/mL in methanol
기술
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
응용 분야
forensics and toxicology
형식
single component solution
저장 온도
−20°C
SMILES string
CN1CCC[C@H]1c2cccnc2
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
InChI key
SNICXCGAKADSCV-JTQLQIEISA-N
유전자 정보
human ... CHRNA4(1137) , CHRNB2(1141)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
A Certified Spiking Solution® applicable for use in LC/MS or GC/MS applications such as nicotine testing, forensic analysis or clinical and diagnostic testing. Nicotine is a highly additive tobacco alkaloid associated with numerous health risks such as heart health, mental health and cancer.
애플리케이션
- Chiral nicotine for neuroreceptor research: S(−)-Nicotine solution is extensively used in neuroreceptor studies, particularly targeting cholinergic receptors. This enantiopure nicotine variant helps in understanding the binding affinity and activity differences between nicotine isomers, contributing to more targeted neuropharmacological interventions (Lu and Gao, 2024).
- Pharmacological experiments in addiction research: The optically active form of S(−)-Nicotine is critical for addiction research, where it is used to investigate the pharmacodynamics and addictive properties of nicotine. Studies using this compound help in developing therapeutic strategies for smoking cessation and understanding the biochemical pathways involved in nicotine addiction (Yang et al., 2024).
- Enantiomer specificity in biochemical studies: High purity S(−)-Nicotine is crucial for assays that require precise control over biochemical properties. Its application in cholinergic receptor assays helps to elucidate the specific interactions and effects of the S(−) enantiomer compared to its R(+) counterpart, thereby enhancing the accuracy of pharmacological models (Mancuso et al., 2024).
법적 정보
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
표적 기관
Eyes,Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
49.5 °F - closed cup
Flash Point (°C)
9.7 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Muhammed Ershad et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 16(4), 452-457 (2020-03-18)
Cigarettes and other tobacco products may be extinguished by submersion in liquids in beverage cans or bottles. Cases of nicotine poisoning in children have been reported following ingestion of such liquids. The aim of this study is to analyze the
Jia Gao et al.
Cell death & disease, 12(6), 508-508 (2021-05-20)
There is limited and discordant evidence on the role of nicotine in diabetic vascular disease. Exacerbated endothelial cell dysregulation in smokers with diabetes is associated with the disrupted adipose function. Adipokines possess vascular protective, anti-inflammatory, and anti-diabetic properties. However, whether
Delia Dempsey et al.
Clinical pharmacology and therapeutics, 76(1), 64-72 (2004-07-02)
Nicotine and a variety of other drugs and toxins are metabolized by cytochrome P450 (CYP) 2A6. Our objective was to evaluate the use of oral nicotine with measurement of the trans-3'-hydroxycotinine (3HC)/cotinine (COT) metabolite ratio as a noninvasive probe of
Jonathan P Winickoff et al.
Pediatrics, 132(1), 109-117 (2013-06-26)
To test whether routine pediatric outpatient practice can be transformed to assist parents in quitting smoking. Cluster RCT of 20 pediatric practices in 16 states that received either CEASE intervention or usual care. The intervention gave practices training and materials
C Feyerabend et al.
British medical journal (Clinical research ed.), 284(6321), 1002-1004 (1982-04-03)
Nicotine concentrations were measured in saliva and urine samples collected from 82 smokers and 56 non-smokers after a morning at work. Each subject answered a series of questions related to their recent intentional or passive exposure to tobacco smoke. All
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