추천 제품
Grade
certified reference material
Quality Level
형태
liquid
특징
Snap-N-Spike®/Snap-N-Shoot®
포장
ampule of 1 mL
제조업체/상표
Cerilliant®
농도
1.0 mg/mL in acetonitrile
기술
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
응용 분야
clinical testing
형식
single component solution
저장 온도
−70°C
SMILES string
CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@H](C)[C@@H]2CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
InChI
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
유전자 정보
human ... FKBP1A(2280)
일반 설명
This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the drug’s narrow therapeutic range. The Snap-N-Spike® format allows laboratories to eliminate weighing operations of hazardous substances such as sirolimus, significantly reducing occupational exposure hazards related to the handling of acutely toxic powders, and provides the ability to spike into their matrix of choice just before use.
Sirolimus, also known as rapamycin, belongs to the group of natural hydrophobic macrolides and is used widely as an immunosuppressive drug. It also shows anti-fungal, anti-candidal, anti-tumor, and anti-proliferative, in addition to immunosuppressive activities. Sirolimus is produced by Streptomyces hygroscopicus bacterium and works as a mammalian Target of Rapamycin (mTOR)inhibitor. It acts by blocking the activation and proliferation of T-lymphocytes, in response to the cytokines and antigens.
Sirolimus, also known as rapamycin, belongs to the group of natural hydrophobic macrolides and is used widely as an immunosuppressive drug. It also shows anti-fungal, anti-candidal, anti-tumor, and anti-proliferative, in addition to immunosuppressive activities. Sirolimus is produced by Streptomyces hygroscopicus bacterium and works as a mammalian Target of Rapamycin (mTOR)inhibitor. It acts by blocking the activation and proliferation of T-lymphocytes, in response to the cytokines and antigens.
애플리케이션
The certified reference solution (CRM) in solution can also be used as follows:
- Multi-residue analysis of sirolimus, tacrolimus, everolimus, and cyclosporine A in whole blood samples by combining Bio-solid phase microextraction with mass spectrometry through a microfluidic open interface (Bio-SPME-MOI-MS/MS)
- Development and validation of a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to determine immunosuppressive drugs― cyclosporine A, tacrolimus, sirolimus, and everolimus in whole blood samples
- Determination of sirolimus in both pig whole blood and lung tissue samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and using a single protein precipitation step for sample preparation
- Analysis of blood samples collected from former transplant patients for the quantification of sirolimus, cyclosporine A, tacrolimus, and everolimus by liquid chromatography and tandem mass spectrometryEstimation of sirolimus, cyclosporine A, and everolimus in the dried matrix on paper discs (DMPD) by liquid chromatography along with tandem mass spectrometry (LC-MS/MS)
특징 및 장점
- Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
- Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
- Rigorously tested through real-time stability studies to ensure accuracy and shelf life
- Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
- Flame sealed under argon into ampoules for long-term shelf life
- Offered in a convenient, DEA-exempt format to improve laboratory efficiency
법적 정보
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
35.6 °F - closed cup
Flash Point (°C)
2 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Benjamin Albert et al.
The Journal of cell biology, 202(2), 201-210 (2013-07-24)
Chromosomes architecture is viewed as a key component of gene regulation, but principles of chromosomal folding remain elusive. Here we used high-throughput live cell microscopy to characterize the conformation and dynamics of the longest chromosome of Saccharomyces cerevisiae (XII). Chromosome
M A Beigh et al.
Journal of biological regulators and homeostatic agents, 27(2), 399-408 (2013-07-09)
S6K1 regulation associates a central role with dynamics of sequential phosphorylations at the hydrophobic motif (T412) and activation loop (T252) of the enzyme, such that the hydrophobic motif phosphorylation supposedly brought about by mTOR- kinase, primes the enzyme for PDK1
Young Joo Shin et al.
Investigative ophthalmology & visual science, 54(7), 4452-4458 (2013-05-30)
To investigate the protective effect of rapamycin against alkali burn-induced corneal damage in mice. BALB/c mice were treated with 0.1 N NaOH to the cornea for 30 seconds. Corneal neovascularization and opacity were clinically evaluated at 1, 2, and 4
Beyza Macunluoglu et al.
JPMA. The Journal of the Pakistan Medical Association, 62(8), 822-825 (2013-07-19)
To investigate the effects of the potent immunosuppressive agents tacrolimus and rapamycin on the number of circulating mature endothelial cells and circulating endothelial progenitor cells in an experimental model. It was an experimental study performed from December 2007 to January
Mario Campone et al.
European journal of cancer (Oxford, England : 1990), 49(12), 2621-2632 (2013-06-06)
Everolimus (EVE; an inhibitor of mammalian target of rapamycin [mTOR]) enhances treatment options for postmenopausal women with hormone-receptor-positive (HR(+)), human epidermal growth factor receptor-2-negative (HER2(-)) advanced breast cancer (ABC) who progress on a non-steroidal aromatase inhibitor (NSAI). This is especially
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.