S-033

JWH-018 5-Pentanoic acid metabolite solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 동의어(들): JWH-018 5-Pentanoic acid
• 실험식(Hill 표기법): C₂₄H₂₁NO₃
• Molecular Weight: 371.43
• EC Number: 200-659-6
• MDL number: MFCD18382139
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329824422
• NACRES: NA.24

속성

• Grade: certified reference material
• Quality Level: 300
• 형태: liquid
• 특징: Snap-N-Spike^®/Snap-N-Shoot^®
• 포장: ampule of 1 mL
• 제조업체/상표: Cerilliant^®
• 농도: 100 μg/mL in methanol
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: forensics and toxicology; forensics and toxicology
• 형식: single component solution
• 저장 온도: −20°C
• SMILES string: O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(CCCCC(O)=O)C4=C3C=CC=C4
• InChI: 1S/C24H21NO3/c26-23(27)14-5-6-15-25-16-21(19-11-3-4-13-22(19)25)24(28)20-12-7-9-17-8-1-2-10-18(17)20/h1-4,7-13,16H,5-6,14-15H2,(H,26,27)
• InChI key: BYIVGHIYNFQIJX-UHFFFAOYSA-N

설명

일반 설명

A secondary urinary metabolite of JWH-018, a synthetic cannabinoid found in many blends of the herbal mixture Spice also known as K2, Genie, or Demon. Our certified Spice cannabinoid solution standards are DEA-exempt allowing laboratories to order these standards without DEA paperwork.

애플리케이션

• Advanced Mass Spectrometry Techniques: JWH-018 has been utilized in pioneering mass spectrometry research to enhance the detection and analysis of synthetic cannabinoids through radial electric field-driven collision-induced dissociation. This technique represents a significant advancement in forensic toxicology and pharmacology, enabling precise identification and quantification of complex substances (Ruan et al., 2023).


• Leukemia and Stem Cell Research: JWH-018 is studied for its potential therapeutic effects on leukemia and leukemic stem cells, offering a novel approach to cancer treatment. This research explores how synthetic cannabinoids can influence cancer pathogenesis and highlights possible applications in developing new cancer therapies (Salcin et al., 2024).


• Yeast Biosensor Development: Research on JWH-018 has contributed to the development of a yeast biosensor capable of cannabinoid detection. This biosensor is designed for biomedical and biotechnological applications, including point-of-use cannabinoid determination, demonstrating the versatility of JWH-018 in receptor research and drug testing (Miettinen et al., 2022).


• Comparative Pharmacology Studies: JWH-018 has been used in comparative studies of molecular signaling between synthetic cannabinoids and TRPV1 channel activation. These studies are crucial for understanding the pharmacological differences between various cannabinoids and their effects on the human body, providing insights into potential therapeutic uses and side effects (Andersen and Walsh, 2021).


• Drug Analysis in Blood Plasma: JWH-018 has also been part of research focused on enhancing drug analysis techniques in blood plasma. By developing non-fouling, sensitive surface-enhanced Raman scattering (SERS) substrates, researchers aim to improve the detection of potent drugs, including JWH-018, directly in complex biological matrices, which is essential for clinical diagnostics and forensic investigations (Masterson et al., 2021).

법적 정보

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H370
• 예방조치 성명서: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 표적 기관: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): 49.5 °F - closed cup
• Flash Point (°C): 9.7 °C - closed cup