05-224

Anti-p53 Antibody, clone BP53-12

clone BP53-12, Upstate^®, from mouse

• 동의어(들): Anti-BCC7, Anti-BMFS5, Anti-LFS1, Anti-P53, Anti-TRP53
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 클론: BP53-12, monoclonal
• application: IHC; IP; WB
• 종 반응성: human
• 기술: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• citations: 48

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: BP53-12, monoclonal
• 종 반응성: human
• 포장: antibody small pack of 25 μL
• 제조업체/상표: Upstate^®
• 기술: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG2a
• NCBI 수납 번호: NM_000546
• UniProt 수납 번호: P04637
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TP53(7157)

설명

일반 설명

The human wild-type p53 protein is a 393 amino acid nuclear phosphoprotein, present in the nucleus of all normal mammalian cells where it appears to be involved in the regulation of cell proliferation. The normal protein has a very short half-life and is present in only minute amounts in normal tissues and cells. In contrast, mutant p53 protein produced by malignant cells is usually a product of a point mutation in the p53 gene leading to substitution of a single amino acid that significantly prolongs the half-life of the protein. The accumulation of high levels of p53 is a potential novel marker for malignancy.

특이성

Recognizes p53.

면역원

Recombinant human wild type p53

애플리케이션

Anti-p53 Antibody, clone BP53-12 is a high quality Mouse Monoclonal Antibody for the detection of p53 & has been validated in IHC, IP & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

품질

routinely evaluated on RIPA lysate of human Raji cells

표적 설명

53 kDa

결합

Replaces: 04-1083

물리적 형태

Format: Purified

Protein A purified

Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

저장 및 안정성

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

분석 메모

Control
Raji cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1