추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
1A6, monoclonal
종 반응성
vertebrates
제조업체/상표
Upstate®
기술
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
동형
IgG2bκ
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... NOS1(4842)
일반 설명
Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Previous studies have shown that nitrotyrosine has been found in inflammatory conditions such as atherosclerotic plaques and rheumatoid arthritis, among others
애플리케이션
Anti-Nitrotyrosine Antibody, clone 1A6 detects level of Nitrotyrosine & has been published & validated for use in IC, IH, IP & WB.
품질
routinely evaluated on peroxynitrite-treated A431 cells; no reaction was noted with non-nitrated proteins
표적 설명
Predicted MW for nitrated-BSA: 66 kDa
물리적 형태
Format: Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in 0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide, and 30% glycerol.
분석 메모
Control
Immunohistochemistry: Human Alzheimer disease brain sections (Methacarn fixed), mouse liver
Immunoblotting: Nitrated-BSA
Indirect ELISA: nitrated-BSA
Indirect immunofluorescence: A549 cells metabolically labeled with 3-nitrotyrosine
Immunohistochemistry: Human Alzheimer disease brain sections (Methacarn fixed), mouse liver
Immunoblotting: Nitrated-BSA
Indirect ELISA: nitrated-BSA
Indirect immunofluorescence: A549 cells metabolically labeled with 3-nitrotyrosine
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(?)-nitro-L-arginine methyl ester hypertensive rats.
Sasser, JM; Molnar, M; Baylis, C
Hypertension null
The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.
Alkam, T; Nitta, A; Mizoguchi, H; Itoh, A; Murai, R; Nagai, T; Yamada, K; Nabeshima, T
Journal of Pharmacology and Experimental Therapeutics null
Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells.
Mastronardi, Maria Letizia, et al.
Fundamental & Clinical Pharmacology, 25, 653-660 (2011)
Peroxynitrite diminishes myogenic activity and is associated with decreased vascular smooth muscle F-actin in rat posterior cerebral arteries.
Maneen, MJ; Hannah, R; Vitullo, L; DeLance, N; Cipolla, MJ
Stroke null
Han Wang et al.
Cardiovascular diabetology, 16(1), 12-12 (2017-01-21)
Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function. The present study examined whether T-cad deficiency increases vascular vulnerability in T2DM. Vascular
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