추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
9.2.7, monoclonal
종 반응성
mouse, human
제조업체/상표
Upstate®
기술
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... MEIS2(4212)
일반 설명
Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Meis1, 2, and 3 are members of the TALE (three amino acid loop extension) family of homeodomain containing proteins. Meis1 binds to Hox and Pbx proteins to form complexes with distinct DNA-binding specificities. Like Hox and Pbx proteins, the overexpression of Meis1 in BHX-2 myeloid leukemias implies a role for this protein in oncogenesis. Two Meis related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and express in normal tissues as well as myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.
특이성
Meis1, Meis2, Meis3 and splice variants
면역원
MBP-conjugated fusion protein corresponding to amino acids 60-390 of mouse Meis1
애플리케이션
Detect Meis 1/2/3 with Anti-Meis 1/2/3 Antibody, clone 9.2.7 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB & IHC.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
품질
routinely evaluated by immunoblot on nuclear extract from K562 cells
표적 설명
Mr ~45-66kDa
결합
Replaces: MABN1071
물리적 형태
Ascites
mouse ascites IgG1 containing 0.05% sodium azide before the addition of glycerol to 30%
저장 및 안정성
2 years at -20°C
분석 메모
Control
K562 nuclear extract
K562 nuclear extract
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Eugeniu Nacu et al.
Nature, 533(7603), 407-410 (2016-04-28)
In salamanders, grafting of a left limb blastema onto a right limb stump yields regeneration of three limbs, the normal limb and two 'supernumerary' limbs. This experiment and other research have shown that the juxtaposition of anterior and posterior limb
Merrick Strotton et al.
Nature methods, 20(9), 1310-1322 (2023-09-01)
Rapid, highly multiplexed, nondestructive imaging that spans the molecular to the supra-cellular scale would be a powerful tool for tissue analysis. However, the physical constraints of established imaging methods limit the simultaneous improvement of these parameters. Whole-organism to atomic-level imaging
The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.
Yousaf A Mian et al.
Leukemia research, 46, 51-60 (2016-04-29)
Mixed lineage leukemias have a relatively poor prognosis and arise as a result of translocations between the MLL(KMT2A) gene and one of multiple partner genes. Downstream targets of MLL are aberrantly upregulated and include the developmentally important HOX genes and
Fabrice Bouilloux et al.
eLife, 5 (2016-02-10)
Although cardio-vascular incidents and sudden cardiac death (SCD) are among the leading causes of premature death in the general population, the origins remain unidentified in many cases. Genome-wide association studies have identified Meis1 as a risk factor for SCD. We
Yu Leng Phua et al.
Physiological reports, 3(10) (2015-10-07)
MicroRNAs are small noncoding RNAs that post-transcriptionally regulate mRNA levels. While previous studies have demonstrated that miRNAs are indispensable in the nephron progenitor and ureteric bud lineage, little is understood about stromal miRNAs during kidney development. The renal stroma (marked
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