1.01544

L-Arginine monohydrochloride

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• 동의어(들): α-Amino-δ-guanidino valerianic acid hydrochloride, alpha-Amino-delta-guanidino valerianic acid hydrochloride, Arg, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride
• 실험식(Hill 표기법): C₆H₁₄N₄O₂ · HCl
• CAS Number: 1119-34-2
• Molecular Weight: 210.66
• Beilstein: 3631658
• MDL number: MFCD00064550
• UNSPSC 코드: 12352209
• EC 인덱스 번호: 214-275-1

속성

• Agency: BP; ChP; JP; Ph. Eur.; USP
• Quality Level: 500
• vapor pressure: <1 Pa ( 20 °C)
• 제품 라인: EMPROVE^® EXPERT
• 분석: 98.5-101.0% dry basis (perchloric acid titration)
• 양식: solid
• pH: 5.7 (20 °C, 100 g/L in H₂O)
• mp: >235 °C
• solubility: water: 730 g/L at 20 °C
• density: 1.42 g/cm³ at 20 °C
• 음이온 미량물: chloride (Cl^-): 16.5-17.1%; sulfate (SO₄^2-): ≤200 ppm
• 양이온 미량물: As: ≤2 ppm; Fe: ≤10 ppm; NH₄⁺: ≤200 ppm; heavy metals (as Pb): ≤10 ppm
• 응용 분야: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• 저장 온도: 2-30°C
• SMILES string: Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
• InChI key: KWTQSFXGGICVPE-WCCKRBBISA-N

설명

일반 설명

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

애플리케이션

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove^® Expert is suitable for high-risk applications.

생화학적/생리학적 작용

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

법적 정보

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable