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Merck
모든 사진(1)

주요 문서

178479

Sigma-Aldrich

Anti-Apolipoprotein E Goat pAb

liquid, Calbiochem®

동의어(들):

Anti-ApoE antibody

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

goat

Quality Level

항체 형태

serum

항체 생산 유형

primary antibodies

클론

polyclonal

양식

liquid

포함

≤0.1% sodium azide as preservative

종 반응성

human, rat, mouse

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
avoid repeated freeze/thaw cycles

동형

IgG

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

일반 설명

Anti-Apolipoprotein E, goat polyclonal, recognizes human apolipoprotein E. Does not cross-react with other apolipoproteins. It is validated for ELISA, immunoprecipitation, and free-floating sections.
Goat polyclonal antibody supplied as serum that has been defibrinated, delipidized and dialyzed against a Tris-HCl buffer. Recognizes the apolipoprotein E protein.
Recognizes human apolipoprotein E. Does not cross-react with other apolipoproteins.
  • Antibody Target Gene Symbol: APOE
  • Target Synonym: AD2, AI255918, APOE2, APOE4, APOEA, APOLIPOPROTEIN E, LDLCQ5, LPG, MGC1571
  • Entrez Gene Name: apolipoprotein E
  • Hu Entrez ID: 348 (Related Antibodies: NE1004)
  • Mu Entrez ID: 11816
  • Rat Entrez ID: 25728
  • 면역원

    Human
    purified recombinant human apolipoprotein E

    애플리케이션

    ELISA (1:8000)

    Immunoprecipitation (see comments)

    Free Floating Sections (see application references)

    포장

    Please refer to vial label for lot-specific concentration.

    경고

    Toxicity: Standard Handling (A)

    물리적 형태

    In 500 mM NaCl, 50 mM Tris-HCl, pH 7.5.

    재구성

    Following initial thaw, aliquot and freeze (-20°C).

    기타 정보

    Monospecific as determined by immunoelectrophoresis (IEP) against twice concentrated pooled human serum. This antibody has also been reported to work with immunoprecipitation. Variables associated with assay conditions will dictate the proper working dilution.

    법적 정보

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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    Storage Class Code

    10 - Combustible liquids

    WGK

    WGK 1

    Flash Point (°F)

    Not applicable

    Flash Point (°C)

    Not applicable


    시험 성적서(COA)

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    문서 라이브러리 방문

    Emilie L Castranio et al.
    Neurobiology of disease, 105, 1-14 (2017-05-16)
    Traumatic brain injury (TBI) is strongly linked to an increased risk of developing dementia, including chronic traumatic encephalopathy and possibly Alzheimer's disease (AD). APOEε4 allele of human Apolipoprotein E (APOE) gene is the major genetic risk factor for late onset
    Jin-Dong Ding et al.
    Proceedings of the National Academy of Sciences of the United States of America, 108(28), E279-E287 (2011-06-22)
    Age-related macular degeneration (AMD) is a leading cause of visual dysfunction worldwide. Amyloid β (Aβ) peptides, Aβ1-40 (Aβ40) and Aβ1-42 (Aβ42), have been implicated previously in the AMD disease process. Consistent with a pathogenic role for Aβ, we show here
    Daniel Da Costa et al.
    Journal of virology, 86(21), 11919-11925 (2012-08-17)
    Hepatitis C virus (HCV) is a human hepatotropic virus, but the relevant host factors restricting HCV infection to hepatocytes are only partially understood. We demonstrate that exogenous expression of defined host factors reconstituted the entire HCV life cycle in human
    Nicholas F Fitz et al.
    Journal of Alzheimer's disease : JAD, 41(2), 535-549 (2014-03-20)
    Passive amyloid-β (Aβ) vaccination has shown significant effects on amyloid pathology in pre-depositing amyloid-β protein precursor (AβPP) mice but the results in older mice are inconsistent. A therapeutic effect of LXR and RXR agonists consisting of improved memory deficits and
    Suzanne E Wahrle et al.
    The Journal of clinical investigation, 118(2), 671-682 (2008-01-19)
    APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, a member of the ATP-binding cassette family of active transporters, lipidates apoE in the CNS. Abca1(-/-) mice have decreased lipid associated with apoE and increased amyloid

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