203694

bpV(bipy)

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation).

• 동의어(들): bpV(bipy), Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
• Linear Formula: K[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (⁵¹V-NMR)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow to orange
• solubility: water: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

A potent inhibitor of phosphotyrosine phosphatase activity (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
phosphotyrosine phosphatase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 18 nM against PTEN

Target K_i: 100 nM for phosphotyrosine phosphatase

포장

Packaged under inert gas

경고

Toxicity: Harmful (C)

재구성

Unstable in solution; reconstitute just prior to use.

기타 정보

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable