361552

GSK-3 Inhibitor IX

InSolution, ≥97%

• 동의어(들): InSolution GSK-3 Inhibitor IX
• 실험식(Hill 표기법): C₁₆H₁₀BrN₃O₂
• CAS Number: 667463-62-9
• Molecular Weight: 356.17
• MDL number: MFCD08705318
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 배송 상태: wet ice
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Specificity was confirmed using various Cdk′s (IC₅₀ = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC₅₀ ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).

생화학적/생리학적 작용

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 5 nM against GSK-3α/β

포장

Packaged under inert gas

경고

Toxicity: Carcinogenic / Teratogenic (D)

물리적 형태

A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.

기타 정보

Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F
• Flash Point (°C): 87 °C