L5783
Lidocaine N-ethyl bromide
analytical standard, for drug analysis
동의어(들):
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide, QX-314
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C16H27BrN2O
CAS Number:
Molecular Weight:
343.30
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24
추천 제품
Grade
analytical standard
Quality Level
기술
HPLC: suitable
gas chromatography (GC): suitable
응용 분야
forensics and toxicology
pharmaceutical (small molecule)
veterinary
형식
neat
SMILES string
[Br-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChI key
DLHMKHREUTXMCH-UHFFFAOYSA-N
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애플리케이션
Lidocaine N-ethyl bromide has been used as a standard in studying the demethylation effect of lidocaine N-ethyl bromide on breast cancer cells in vitro using colorimetric assay.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
생화학적/생리학적 작용
A quaternary derivative of lidocaine that is not membrane permeable. Blocks both fast Na+-dependent action potentials and voltage-dependent, non-inactivating Na+ conductance.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro
Lirk.P, et al.
British Journal of Anaesthesia, 113 (2014)
Kimbria J Blake et al.
Nature communications, 9(1), 37-37 (2018-01-04)
The hallmark of many bacterial infections is pain. The underlying mechanisms of pain during live pathogen invasion are not well understood. Here, we elucidate key molecular mechanisms of pain produced during live methicillin-resistant Staphylococcus aureus (MRSA) infection. We show that
D P Roberson et al.
British journal of pharmacology, 164(1), 48-58 (2011-04-05)
We have developed a strategy to target the permanently charged lidocaine derivative lidocaine N-ethyl bromide (QX-314) selectively into nociceptive sensory neurons through the large-pore transient receptor potential cation channel subfamily V (TRPV1) noxious heat detector channel. This involves co-administration of
Christian Brenneis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 315-326 (2013-01-04)
Specific somatosensations may be processed by different subsets of primary afferents. C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but not mechanical pain detectors. To phenotype in rats the sensory function of TRPV1(+) afferents, we rapidly
Huan Luo et al.
Frontiers in neuroanatomy, 11, 115-115 (2018-01-10)
Layer 2/3 (L2/3) excitatory neurons in the neocortex make major contributions to corticocortical connections and therefore function to integrate information across cortical areas and hemispheres. Recent evidence suggests that excitatory neurons in L2/3 can have different properties. Sparse evidence from
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