N5410

Nicotinic acid

meets USP testing specifications

• 동의어(들): 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃
• 실험식(Hill 표기법): C₆H₅NO₂
• CAS Number: 59-67-6
• Molecular Weight: 123.11
• Beilstein: 109591
• EC Number: 200-441-0
• MDL number: MFCD00006391
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24897734
• NACRES: NA.21

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• Agency: USP/NF; meets USP testing specifications
• 분석: 99.0-101.0% dry basis
• 형태: powder
• 색상: white
• mp: 236-239 °C (lit.)
• 응용 분야: pharmaceutical (small molecule)
• SMILES string: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• 유전자 정보: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

설명

일반 설명

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

애플리케이션

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

생화학적/생리학적 작용

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 379.4 °F - closed cup
• Flash Point (°C): 193 °C - closed cup
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves