Y0001596

Diacerein impurity B

European Pharmacopoeia (EP) Reference Standard

• 동의어(들): Aloe-emodin, 1,8-Dihydroxy 3-hydroxymethylanthraquinone, 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 3-Hydroxymethylchrysazine, Rhabarberone
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 481-72-1
• Molecular Weight: 270.24
• Beilstein: 2059062
• MDL number: MFCD00017373
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329831502
• NACRES: NA.24

속성

• 생물학적 소스: synthetic
• Grade: pharmaceutical primary standard
• Agency: EP
• API family: diacerein
• 형태: solid
• 제조업체/상표: EDQM
• 기술: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: 2-8°C
• SMILES string: OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
• InChI: 1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
• InChI key: YDQWDHRMZQUTBA-UHFFFAOYSA-N

설명

일반 설명

Diacerein is known to be a suitable drug to treat osteoarthritis and prevent vascular diseases. It is a semi-synthetic anthraquinone derivative which acts by inhibiting the production of interleukin-1 and secretion of metalloproteases.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Diacerein impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

생화학적/생리학적 작용

Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable