A1487

AG-205

≥98% (HPLC)

• 동의어(들): cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone, cis-5-({[1-(4-chlorophenyl)-1H-tetraazol-5-yl]sulfanyl}acetyl)-2,8-dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
• 실험식(Hill 표기법): C₂₂H₂₃ClN₆OS
• CAS Number: 1375078-57-1
• Molecular Weight: 454.98
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329770709
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: off-white to brown
• solubility: DMSO: >9 mg/mL (warmed)
• 저장 온도: 2-8°C
• SMILES string: CN1CC[C@@H]2[C@H](C1)c3cc(C)ccc3N2C(=O)CSc4nnnn4-c5ccc(Cl)cc5
• InChI: 1S/C22H23ClN6OS/c1-14-3-8-19-17(11-14)18-12-27(2)10-9-20(18)28(19)21(30)13-31-22-24-25-26-29(22)16-6-4-15(23)5-7-16/h3-8,11,18,20H,9-10,12-13H2,1-2H3/t18-,20-/m1/s1
• InChI key: GJNBAISSZRNGTM-UYAOXDASSA-N

설명

애플리케이션

AG-205 has been used to investigate the neuroprotective effects of norgestrel on stressed photoreceptors. It has also been used to study the effect of blocking progesterone receptor membrane component 1 in 661W cells.

생화학적/생리학적 작용

AG-205 is a Pgrmc1 (progesterone receptor membrane component 1) inhibitor. AG-205 alters the spectroscopic properties of the Pgrmc1-heme complex. AG-205 inhibits cancer cell viability and cancer cell progression. acting preferentially on Pgrmc1-expressing cells.

Pgrmc1 is a cytochrome associated protein. It is found to be upregulated in several cancer types such as breast, lung and gastric cancer. Pgrmc1 regulates the epidermal growth factor signaling.

특징 및 장점

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable