A3411

Aminopterin

powder, BioReagent, suitable for cell culture

• 동의어(들): (S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid, 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid
• 실험식(Hill 표기법): C₁₉H₂₀N₈O₅
• CAS Number: 54-62-6
• Molecular Weight: 440.41
• Beilstein: 69045
• EC Number: 200-209-9
• MDL number: MFCD00036692
• UNSPSC 코드: 12352205
• PubChem Substance ID: 24890768
• NACRES: NA.75

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 제품 라인: BioReagent
• 분석: ≥97%
• 양식: powder
• 기술: cell culture | mammalian: suitable
• 색상: yellow
• solubility: 2 M NaOH: 50 mg/mL; DMSO: soluble
• ε (흡광계수): 24,500 at 282 nm in 0.1 M NaOH at 1 M; 25,700 at 261 nm in 0.1 M NaOH at 1 M; 8,100 at 373 nm in 0.1 M NaOH at 1 M
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
• InChI: 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
• InChI key: TVZGACDUOSZQKY-LBPRGKRZSA-N
• 유전자 정보: human ... FPGS(2356) ; mouse ... Fpgs(14287)

설명

애플리케이션

Aminopterin has been used in the production of anti- neurogranin antibodies.

생화학적/생리학적 작용

Aminopterin is found to inhibit growth, embryogenesis and has toxic effects in mice models. It serves as a abortifacient. Aminopterin is known to reduce the effects of acute leukemia in children.

Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

결합

More potent, but more toxic, than methotrexate.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300,H315,H319,H341,H360FD
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges