A4036

Adenosine

suitable for cell culture, BioReagent

• 동의어(들): 9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside
• 실험식(Hill 표기법): C₁₀H₁₃N₅O₄
• CAS Number: 58-61-7
• Molecular Weight: 267.24
• Beilstein: 93029
• EC Number: 200-389-9
• MDL number: MFCD00005752
• UNSPSC 코드: 12352207
• eCl@ss: 32160413
• PubChem Substance ID: 24890739
• NACRES: NA.75

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 제품 라인: BioReagent
• 분석: ≥99% (HPLC)
• 양식: powder
• 기술: cell culture | mammalian: suitable
• mp: 234-236 °C (lit.)
• solubility: 1 M NH4OH: 50 mg/mL, clear, colorless
• 저장 온도: 2-8°C
• SMILES string: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI key: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• 유전자 정보: human ... ADA(100) , ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , ERBB2(2064) , ERBB4(2066) ; rat ... Adcy2(81636) , Adora1(29290) , Adora2a(25369) , Adora3(25370)

설명

일반 설명

The nucleoside adenosine consists of the purine adenine and the sugar ribose. Thus, it is also referred as adenine-D-ribose. Adenosine is an important molecule that forms nucleotides, which is a part of nucleic acids forming the DNA and RNA. The nucleotides include: adenosine monophosphate, adenosine diphosphate and adenosine triphosphate.

애플리케이션

Adenosine has been used as a supplement in DMEM (Dulbecco′s modified Eagle medium):

• to evaluate the outgrowth of the interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts
• to maintain the CGR8 ES (germ-line competent cell line) cells
• for plasmid transfection and cloning of embryonic stem cells

생화학적/생리학적 작용

Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A₁ adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A₂ adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).

Endogenous neurotransmitter. Cardioprotective effects may relate to activation of A₁ adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A₂ adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).

Tissue injury, ischemia and abnormal cell proliferation stimulate the release of adenosine. Adenosine helps in countering the effects of reduced oxygen and energy in organs such as heart, brain and skeletal muscles mediating vasodialation. It delivers its action through G protein-coupled receptors. Adenosine also reduces the release of neurotransmitters and cellular metabolism.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)