콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

E2387

Sigma-Aldrich

NECA

≥98% (TLC), powder, adenosine receptor agonist

동의어(들):

NECA

로그인조직 및 계약 가격 보기


About This Item

실험식(Hill 표기법):
C12H16N6O4
CAS Number:
Molecular Weight:
308.29
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

제품명

5′-(N-Ethylcarboxamido)adenosine, powder

양식

powder

Quality Level

색상

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.)
DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.)
0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.)
H2O: insoluble
ethanol: soluble (Solutions may be stored for several days at 4 °C.)

저장 온도

2-8°C

SMILES string

CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1

InChI key

JADDQZYHOWSFJD-FLNNQWSLSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

5′-(N-Ethylcarboxamido)adenosine stimulates vasodilation in the pulmonary circulation through A2-adenosine-receptor activation.

애플리케이션

5′-(N-Ethylcarboxamido)adenosine has been used:
  • for the purification of human adenosine A2Areceptor (A2AR) in decylmaltoside (DM)
  • to determine nonspecific binding of adenosine receptors
  • to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

생화학적/생리학적 작용

Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.

특징 및 장점

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

픽토그램

Skull and crossbones

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

이미 열람한 고객

Docking screens for dual inhibitors of disparate drug targets for Parkinson?s disease
Jaiteh M, et al.
Journal of Medicinal Chemistry, 61(12), 5269-5278 (2018)
Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach
Paz OS, et al.
European Journal of Medicinal Chemistry, 136, 487-496 (2017)
5-(N-ethylcarboxamido) adenosine desensitizes the A2b-adenosine receptor in lung circulation
Haynes Jr J, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 276(6), H1877-H1883 (1999)
Shanshan Liu et al.
Protein science : a publication of the Protein Society, 25(12), 2209-2215 (2016-09-27)
The molecular chaperone Hsp90 facilitates the folding and modulates activation of diverse substrate proteins. Unlike other heat shock proteins such as Hsp60 and Hsp70, Hsp90 plays critical regulatory roles by maintaining active states of kinases, many of which are overactive
Rony Nehmé et al.
PloS one, 12(4), e0175642-e0175642 (2017-04-21)
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G proteins, and

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.