I4125

Inosine

≥99% (HPLC)

• 동의어(들): (−)-Inosine, Hypoxanthine 9-β-D-ribofuranoside
• 실험식(Hill 표기법): C₁₀H₁₂N₄O₅
• CAS Number: 58-63-9
• Molecular Weight: 268.23
• Beilstein: 624896
• EC Number: 200-390-4
• MDL number: MFCD00066770
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24896051
• NACRES: NA.51

속성

• Quality Level: 200
• 분석: ≥99% (HPLC)
• mp: 222-226 °C (dec.) (lit.)
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3C(=O)NC=Nc23
• InChI: 1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1
• InChI key: UGQMRVRMYYASKQ-KQYNXXCUSA-N

설명

일반 설명

Inosine is a non-canonical nucleotide majorly present as monophosphate. It has ability to base pair with deoxythymidine, deoxyadenosine and deoxyguanosine. Incorporation of inosine in place of guanine modulates translational events. Inosine has antioxidant, anti-inflammatory and neuroprotective functionality. Inosine is prescribed as a therapeutic supplement for nerve injury, inflammation and oxidative stress. It modulates biological processes through adenosine receptors. Its enhances neurite outgrowth in depressive disorders via adenosine receptors. Inosine is also used for treating sepsis in infections.

애플리케이션

Inosine has been used:

• as a medium supplement in nucleotide rescue experiments in pancreatic cancer cell lines.
• as a component in holidic (synthetic) medium and in larval two-choice preference assay.
• as a reference standard in mass spectroscopy.

생화학적/생리학적 작용

Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage. Inosine may be used in studies of the process A-to-I RNA editing.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)