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Merck
모든 사진(2)

주요 문서

A6500

Sigma-Aldrich

Acetylcholine bromide

≥99%

동의어(들):

ACh

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About This Item

Linear Formula:
(CH3)3N(Br)CH2CH2OCOCH3
CAS Number:
Molecular Weight:
226.11
Beilstein:
3572117
EC Number:
MDL number:
UNSPSC 코드:
51151519
PubChem Substance ID:
NACRES:
NA.25

Quality Level

분석

≥99%

양식

powder

mp

140-143 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

저장 온도

−20°C

SMILES string

[Br-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.BrH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChI key

ZEHGKSPCAMLJDC-UHFFFAOYSA-M

유전자 정보

human ... CHRM3(1131)

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애플리케이션

Acetylcholine is an endogenous neurotransmitter at cholinergic synapses that amplifies action potential of the sarcolemma thereby inducing muscle contractions. Acetylcholine bromide is used as an acetylcholine receptor agonist to identify, characterize and differentiate among types of cholinergic receptors. Acetylcholine bromide is used as an inhibitor to identify and characterize natural and mutated butyrylcholinesterase(s).

생화학적/생리학적 작용

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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문서 라이브러리 방문

Scott A Hollingsworth et al.
Nature communications, 10(1), 3289-3289 (2019-07-25)
Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly given recent structures that reveal
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Vascular pharmacology, 87, 83-91 (2016-08-28)
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Sonia Donzelli et al.
Scientific reports, 7(1), 9938-9938 (2017-09-01)
Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely understood, pharmacological donors show broad therapeutic promise and are in clinical trials. Mass spectrometry and site-directed mutagenesis showed that chemically distinct HNO donors 1-nitrosocyclohexyl acetate or Angeli's salt
Fábio H Silva et al.
PloS one, 11(12), e0166291-e0166291 (2016-12-10)
Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of corpus cavernosum in sickle cell disease. Thus, this study aimed to evaluate the functional and molecular alterations of sympathetic
James A Angus et al.
European journal of pharmacology, 804, 111-116 (2017-03-17)
Endothelin receptor antagonists are approved for pulmonary arterial hypertension. Development of selective ET Human isolated pulmonary (i.d. 5.5mm) and human radial (i.d. 3.23mm) artery ring segments were mounted in organ baths for isometric force measurement. Single concentration-contraction curves to endothelin-1

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