A2181

Acetyl coenzyme A lithium salt

≥93% (HPLC)

• 동의어(들): Acetyl-CoA, Acetyl-S-CoA Li₃
• 실험식(Hill 표기법): C₂₃H₃₈N₇O₁₇P₃S · xLi⁺
• CAS Number: 32140-51-5
• Molecular Weight: 809.57 (free acid basis)
• MDL number: MFCD00167406
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24890633
• NACRES: NA.51

속성

• Quality Level: 300
• 분석: ≥93% (HPLC)
• 형태: powder
• solubility: H₂O: soluble 100 mg/mL, clear, colorless
• 저장 온도: −20°C
• SMILES string: [Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23
• InChI: 1S/C23H38N7O17P3S.3Li/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;;;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);;;/q;3*+1/p-3/t13-,16-,17-,18+,22-;;;/m1.../s1
• InChI key: FTRFBNATWBKIQU-JHJDYNLLSA-K
• 유전자 정보: human ... CHAT(1103) , HAT1(8520) , KAT2A(2648) , KAT2B(8850) , KAT5(10524) ; mouse ... HAT1(107435) , KAT2A(14534) , KAT2B(18519) , KAT5(81601) ; rat ... HAT1(296501) , KAT2A(303539) , KAT2B(301164) , KAT5(192218)

설명

애플리케이션

Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [¹⁴C] chloramphenicol and 0.5mM acetyl-CoA.

An essential cofactor in enzymatic acetyl transfer reactions.

생화학적/생리학적 작용

Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment. Defects in the gene cause myasthenic syndrome associated with episodic apnea.

Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.

물리적 특성

This moisture-sensitive powder should be stored desiccated at −20°C.

제조 메모

Prepared enzymatically

재구성

Acetyl CoA is soluble in deionized water at 100 mg/mL. Acetyl CoA is stable in neutral and moderately acidic solutions but will hydrolyze in alkaline and strongly acidic solutions. Aqueous solutions stored in single-use aliquots are stable for up to two weeks at −20°C and up to 6 months at −80°C.

기타 정보

For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves