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Merck
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주요 문서

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C0563

Sigma-Aldrich

Cardiolipin sodium salt from bovine heart

≥97% (TLC), lyophilized powder

동의어(들):

Diphosphatidylglycerol

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모든 사진(1)

About This Item

MDL number:
MFCD00071040
UNSPSC 코드:
12352211
NACRES:
NA.25

생물학적 소스

bovine heart

Quality Level

200

분석

≥97% (TLC)

양식

lyophilized powder

지질 유형

phosphoglycerides

배송 상태

ambient

저장 온도

−20°C

관련 카테고리

일반 설명

Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. Cardiolipin is an important component of ATP synthase enzyme.

애플리케이션

Cardiolipin sodium salt from bovine heart has been used:
  • as a phospholipid standard in thin layer chromatography for the quantification of total mitochondrial lipids of Neurospora crassa(89)
  • as an internal standard in reverse phase high performance liquid chromatography (RP-HPLC) for quantification of bacterial lipid extracts(90)
  • as an antigen to evaluate IgM reaction in systemic lupus erythematosus (SLE) patients(91)

생화학적/생리학적 작용

Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component. Inhibits cell attachment of fibronectin, vitronectin and Type I collagen.

포장

packaged under argon

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000377321
0000372460
0000372466
0000361777
0000348945

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리 방문

Ze-Wei Ma et al.
Acta pharmacologica Sinica, 39(6), 1012-1021 (2017-12-22)
Humanin (HN) is a 24-residue peptide identified from the brain of a patient with Alzheimer's disease (AD). HN has been found to protect against neuronal insult caused by Aβ peptides or transfection of familial AD mutant genes. In order to
Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to beta-barrel protein assembly and maintenance of mitochondrial morphology
Wideman JG, et al.
PLoS ONE, 8(8), e71837-e71837 (2013)
Lu Luo et al.
The Journal of biological chemistry, 289(46), 31708-31718 (2014-10-08)
Bax is a pro-apoptotic Bcl-2 family protein. The activated Bax translocates to mitochondria, where it forms pore and permeabilizes the mitochondrial outer membrane. This process requires the BH3-only activator protein (i.e. tBid) and can be inhibited by anti-apoptotic Bcl-2 family
Lenette L Lu et al.
Nature medicine, 25(6), 977-987 (2019-05-22)
Exposure to Mycobacterium tuberculosis (Mtb) results in heterogeneous clinical outcomes including primary progressive tuberculosis and latent Mtb infection (LTBI). Mtb infection is identified using the tuberculin skin test and interferon-γ (IFN-γ) release assay IGRA, and a positive result may prompt
Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases
Duncan AL, et al.
Proceedings of the National Academy of Sciences of the USA, 113(31), 8687-8692 (2016)
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