C1649

Cardiolipin solution from bovine heart

4.7-5.3 mg/mL in ethanol, ≥97% (TLC)

• 동의어(들): Diphosphatidylglycerol solution
• EC Number: 200-578-6
• MDL number: MFCD00071040
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 생물학적 소스: bovine heart
• Quality Level: 300
• 분석: ≥97% (TLC)
• 양식: liquid
• 포장: glass bottle of
• 농도: 4.7-5.3 mg/mL in ethanol
• 색상: colorless to yellow
• 응용 분야: general analytical; lipidomics; metabolomics
• 작용기: phospholipid
• 지질 유형: phosphoglycerides
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

일반 설명

Cardiolipin (CL) is a complex lipid with a dimeric structure. It has four acyl chains and two phosphatidyl moieties. Its phosphatidyl moieties are linked to the glycerol backbone. Around 15-20 percent of the inner mitochondrial membrane accounts for cardiolipin.

Cardiolipin is a unique phospholipid found exclusively within the mitochondrial inner membrane. This specific localization allows Cardiolipin to exert crucial influence on mitochondrial structure and function. Deviations in Cardiolipin content, structure, or localization can lead to impaired mitochondrial activity, contributing to various diseases like cancer, neurological disorders, cardiovascular conditions, and metabolic diseases. As Cardiolipin plays a crucial role in mitochondrial function, it holds immense potential for biomarker development and finds application in cardiovascular, neuroscience, cancer, diabetes, and metabolomics research.

애플리케이션

Cardiolipin solution from bovine heart has been used:

• for coating Corning 96-well enzyme immunoassay/radioimmunoassay (EIA/RIA) plate to perform enzyme-linked immunosorbent assay (ELISA)-based cardiolipin binding assay
• in lipid analysis along with phosphatidylglycerol (PG) to comigrate the radiolabeled lipids to identify PG and cardiolipin (CL)
• in coating ELISA plates for antiphospholipid antibodies (aPL) assays

생화학적/생리학적 작용

Cardiolipin (CL) plays a key role in mitochondrial biogenesis, fusion and fission, respiration, and protein import. It participates in the cellular processes outside of the mitochondria like cell wall biogenesis, aging, vacuole homeostasis, the cell cycle, and apoptosis. CL is also involved in heart function, autophagy/mitophagy, and the protein kinase C (PKC) pathway.

Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component and can inhibit cell attachment of fibronectin, vitronectin, and type I collagen.

특징 및 장점

• High-quality molecule suitable for mulitple research applications
• Commonly employed in Metabolomics and Biochemical studies

기타 정보

>80% polyunsaturated fatty acid content, primarily linoleic acid.

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물리적 형태

Approximately 5 mg/ml in ethanol.

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H319
• 예방조치 성명서: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 55.4 °F - closed cup
• Flash Point (°C): 13 °C - closed cup