추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
C-1, monoclonal
형태
buffered aqueous solution
분자량
antigen 16 kDa
종 반응성
feline, turtle, monkey, rabbit, bovine, human, rat, chicken
반응하면 안 됨
(chameleon), frog, goldfish
기술
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CRABP1(1381)
rat ... Crabp1(25061)
일반 설명
Cellular retinoic acid-binding protein 1 is a protein encoded by the CRABP1 gene in humans. It encodes a specific binding protein for a vitamin A family member. It is also referred as RBP5, CRABP, CRABPI and CRABP-I.
면역원
performic acid oxidized CRABP 1, purified from bovine retina.
애플리케이션
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse is suitable for the following applications:
- indirect ELISA
- western blotting at a dilution of 1:1000
- immunofluorescence at a working dilution of 1:250
생화학적/생리학적 작용
Cellular retinoic acid-binding protein 1 (CRABP1) is a prognostic marker for adenocarcinoma and clear cell carcinoma that exhibits chemo-resistance. It is a is a modulator of retinoic acid and plays an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 also functions as a tumor-suppressor in esophageal epithelium and its epigenetic silencing may play a pivotal role during esophageal carcinogenesis.
물리적 형태
Solution in phosphate buffered saline containing 0.05% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yu-Lung Lin et al.
Endocrinology, 158(9), 3004-3014 (2017-09-16)
Retinoic acid (RA) is the active ingredient of vitamin A. It exerts its canonical activity by binding to nuclear RA receptors (RARs) to regulate gene expression. Increasingly, RA is also known to elicit nongenomic RAR-independent activities, most widely detected in
Yi-Chiung Hsu et al.
Molecular carcinogenesis, 62(12), 1935-1946 (2023-08-29)
Cellular retinoic acid binding protein 1 (CRABP1) participates in the regulation of retinoid signaling. Previous studies showed conflicting results regarding the role of CRABP1 in tumor biology, including protumorigenic and tumor-suppressive effects in different types of cancer. Our bioinformatics analyses
Sung Wook Park et al.
The Journal of endocrinology, 236(3), 151-165 (2018-01-27)
Excessive and/or persistent activation of calcium-calmodulin protein kinase II (CaMKII) is detrimental in acute and chronic cardiac injury. However, intrinsic regulators of CaMKII activity are poorly understood. We find that cellular retinoic acid-binding protein 1 (CRABP1) directly interacts with CaMKII
M W Kelley et al.
Development (Cambridge, England), 119(4), 1041-1053 (1993-12-01)
The mammalian organ of Corti has one of the most highly ordered patterns of cells in any vertebrate sensory epithelium. A single row of inner hair cells and three or four rows of outer hair cells extend along its length.
Shawna D Persaud et al.
Cellular signalling, 25(1), 19-25 (2012-09-18)
All-trans retinoic acid (atRA), one of the active ingredients of vitamin A, exerts canonical activities to regulate gene expression mediated by nuclear RA receptors (RARs). AtRA could also elicit certain non-canonical activities including, mostly, rapid activation of extracellular signal regulated
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